Gut microbiota in lymph node tuberculosis, Shenzhen, China
Case-control metagenomic study of 17 gut microbiome samples from adults in Shenzhen, China, comparing lymph node tuberculosis patients with healthy individuals, alongside plasma metabolomics to assess SCFA-related dysbiosis. machine-written summary
17 samples · 17 runs · CN · Age unknown · 2025 · 13.42 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 136 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC12298930 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 17 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 17 | 100% | ||||
| country | 17 | 100% | 17 | |||
| health_condition | 17 | 100% | 17 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 17 | 100% | 17 | |||
| detailed_location | 17 | 100% | ||||
| health_condition_detail | 17 | 100% | 17 | |||
| latitude | 17 | 100% | 17 | |||
| location_locality | 17 | 100% | 17 | |||
| location_region | 17 | 100% | 17 | |||
| longitude | 17 | 100% | 17 |
- Disorders of Gut Microbiota and Plasma Metabolic Profiles May Be Associated with Lymph Node Tuberculosis. 2025 PMID 40731966 PMC12298930 own_data
Archive description
The association of gut microbiota with lymph node tuberculosis (LNTB) remains unexplored. This study employed metagenomic sequencing and plasma metabolomics analyses to investigate the role of gut microbiota in LNTB patients. Significant alterations in gut microbial diversity were observed in LNTB patients, characterized by a notable reduction in bacterial taxa involved in short chain fatty acid (SCFA) synthesis, including Ruminococcus, Faecalibacterium, Roseburia, and Blautia, compared to healthy individuals.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.60. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.description · “gut microbiota in LNTB patients”
- body site study.title · “Gut Microbiota Are Associated with Lymph Node Tuberculosis”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN48946918 | collection_date | 2025-01 | R1 | 0.90 | biosample.attribute:collection_date | 2025-01 |
| SAMN48946918 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Shenzhen |
| SAMN48946918 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:alias | Health4 |
| SAMN48946918 | health_condition_detail | Health | R1 | 0.70 | sample.name_rule:alias | Health4 |
| SAMN48946918 | latitude | 22.5500 | R1 | 0.90 | biosample.attribute:lat_lon | 22.55 N 114.05 E |
| SAMN48946918 | location_locality | Shenzhen | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Shenzhen |
| SAMN48946918 | location_region | Guangdong | R1 | 0.60 | biosample.attribute:lat_lon | 22.55 N 114.05 E |
| SAMN48946918 | longitude | 114.0500 | R1 | 0.90 | biosample.attribute:lat_lon | 22.55 N 114.05 E |
Sequencing
17 runs over 17 samples · mean 13.09 Gbp per run (median 13.42 Gbp, total 222.61 Gbp; 17 runs with a base count) · layout PAIRED 17 · platform ILLUMINA 17 · models Illumina NovaSeq 6000 (17) · 100% of runs with a Sandpiper profile · first public 2025-06-09
Authors (12)
Long Y first · Huang J · Zheng S · Bai S · Liu Z · Li X · Gao W · Ke X · Tang Y · Yang L · Wang H · Li G last
Downloads
PRJNA1273449.csv.gz (1.4 KB) · parquet (70.5 KB) — all 17 samples, every field with route and confidence · PRJNA1273449_determinations.csv.gz (1.5 KB) — 136 evidence rows