Maternal microbiome, offspring atopic dermatitis, Singapore
Case-control study of 325 samples from Singapore examining links between the maternal-prenatal gut microbiome and immune-metabolome and offspring susceptibility to atopic dermatitis. machine-written summary
325 samples · 325 runs · SG · Infant / toddler · 2025 · 5.54 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 325 sample values (country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 325 sample values (collection date) · PMC13214156 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolvedmother–infant — not resolved
Schedule stated by the source: “Mothers: 1st (11–13 wk) and 3rd (34–36 wk) trimester; offspring: 3 weeks, 3 months, 6 months of age” (time origin: gestation (mothers) / birth (offspring)).
128 mother–offspring dyads (64 AD cases, 64 controls; S-PRESTO); maternal and offspring stool sequenced.
Genera, mean relative abundance over 317 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 325 | 100% | 325 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 325 | 100% | 325 |
- Maternal-prenatal gut microbiome-systemic metabolome perturbations and T<sub>H</sub>2-skewed immunity link to offspring gut microbiome disruption and atopic dermatitis susceptibility. PMID 41998770 PMC13214156 curated
Archive description
Our findings uncover plausible biological links through which the maternal-prenatal gut microbiome and systemic immune-metabolome modulates the early-life gut microbiome-metabolome environment in offspring, contributing to AD susceptibility.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.description · “which the maternal-prenatal gut microbiome and systemic”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “immune-metabolome modulates the early-life gut microbiome-metabolome environment”
- life stage study.title · “Maternal -Prenatal Signature Underlying”
- life stage study.description · “through which the maternal -prenatal gut microbiome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN48951460 | collection_date | 2015-02/2018-04 | R3 | 0.70 | paper.fulltext.methods | Chinese, Malay or Indian women aged 18–35 years between February 2015 and |
| SAMN48951460 | country | SG | R1 | 0.90 | biosample_attr | Singapore |
Sequencing
325 runs over 325 samples · mean 5.62 Gbp per run (median 5.54 Gbp, total 1,826.66 Gbp; 325 runs with a base count) · layout PAIRED 325 · platform ILLUMINA 325 · models Illumina HiSeq 2500 (325) · 98% of runs with a Sandpiper profile · first public 2025-06-23
Authors (31)
Ng DZW first · Yap GC · Tay CJX · Huang CH · Zhao S · Low A · Tham EH · Loo EXL · Shek LP · Goh A · Chong KW · Goh SH · Cheng ZR · Van Bever HPS · Teoh OH · Lee YS · Yap F · Tan KH · Chong YS · Chan SY · Eriksson JG · Godfrey KM · Lay C · Knol J · Schuster SC · Lai JS · Chong MF · Lee JWJ · Lee BW · Chan ECY · Ta LDH last
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJNA1273620.csv.gz (8.6 KB) · parquet (82.5 KB) — all 325 samples, every field with route and confidence · PRJNA1273620_determinations.csv.gz (2.8 KB) — 650 evidence rows