Metagenomes in microplastics & polyphenol trial, Shanghai
198 fecal samples from adults in Shanghai, China, from a two-phase trial on microplastic exposure and a 28-day randomized, double-blind, placebo-controlled dietary supplement (composite polyphenols) intervention. machine-written summary
198 samples · 198 runs · CN · Age unknown · 2025 · 6.53 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,188 sample values (collection date, country, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 198 sample values (location site) · PMC13365578 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-microbial dietary supplement (vitamins design randomized_controlled_trial · population healthy_control · Composite polyphenols supplement, 28-day RCT vs placebo
“28-day randomized, double-blind, placebo-controlled trial” — abstract:41932890 (study level; per-sample arms are in the intervention column below)
Genera, mean relative abundance over 157 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 198 | 100% | ||||
| country | 198 | 100% | 198 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 198 | 100% | 198 | |||
| detailed_location | 198 | 100% | ||||
| latitude | 198 | 100% | 198 | |||
| location_locality | 198 | 100% | 198 | |||
| location_region | 198 | 100% | 198 | |||
| location_site | 198 | 100% | 198 | |||
| longitude | 198 | 100% | 198 |
- Composite polyphenols mitigate microplastic exposure-related immune disturbances: a two-phase population trial. 2026 PMID 41932890 PMC13365578 own_data
Archive description
This study firstly designed a two-phase population trial, comprising a pilot population (n = 151) to investigate the MP toxicity mechanisms and a 28-day randomized, double-blind, placebo-controlled trial (n = 98) evaluating the effects of an intervention with composite polyphenols. Two-stage fecal samples were used for metagenomic sequencing.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.55. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.title · “two-phase population trial”
- body site study.description · “Two-stage fecal samples”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN48977318 | collection_date | 2024-04-23 | R1 | 0.90 | biosample.attribute:collection_date | 2024-04-23 |
| SAMN48977318 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: shanghai |
| SAMN48977318 | latitude | 31.4100 | R1 | 0.90 | biosample.attribute:lat_lon | 31.41 N 120.53 E |
| SAMN48977318 | location_locality | Shanghai | R1 | 0.85 | biosample.attribute:geo_loc_name | China: shanghai |
| SAMN48977318 | location_region | Jiangsu Sheng | R1 | 0.60 | biosample.attribute:lat_lon | 31.41 N 120.53 E |
| SAMN48977318 | location_site | School of Public Health, Fudan University | R3 | 0.70 | paper.fulltext.methods | The trial was conducted at the School of Public Health, Fudan University |
| SAMN48977318 | longitude | 120.5300 | R1 | 0.90 | biosample.attribute:lat_lon | 31.41 N 120.53 E |
Sequencing
198 runs over 198 samples · mean 6.69 Gbp per run (median 6.53 Gbp, total 1,325.56 Gbp; 198 runs with a base count) · layout PAIRED 198 · platform ILLUMINA 198 · models Illumina NovaSeq 6000 (198) · 79% of runs with a Sandpiper profile · first public 2025-10-02 – 2025-10-23
Authors (14)
Zhao L first · Zheng J · Shen Y · Xu X · Liu X · Yu J · Li J · Yang B · Chen L · Wang F · Liu S · Peng X · Du J · Dong R last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1274175.csv.gz (5.5 KB) · parquet (77.2 KB) — all 198 samples, every field with route and confidence · PRJNA1274175_determinations.csv.gz (8.0 KB) — 1,386 evidence rows