Sibling microbiome transfer and allergy risk, Dublin cohort
Longitudinal cohort study of 353 samples from Dublin, Ireland, examining sibling-associated gut microbial taxa and metabolic pathways (e.g., short chain fatty acid and tryptophan metabolism) linked to allergy development. machine-written summary
353 samples · 353 runs · IE · Infant / toddler · 2025 · 9.86 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,059 sample values (collection date, country, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC12486347 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 331 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 353 | 100% | 353 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 353 | 100% | 353 | |||
| collection_date | 353 | 100% | 353 |
- Microbial Sharing Between Siblings Supports Metabolic Functions Protective Against Allergy. 2025 PMID 40879391 PMC12486347 own_data
Archive description
Horizontal sibling-to-infant transfer of microbes is thought to be important for shaping microbiome development and consequently its interaction with host immunological processes. In this study, we identified taxa and microbial metabolic pathways associated with siblings in the home, such as short chain fatty acid and tryptophan metabolism. Long-lasting close contact between cohabiting individuals that provides commensal microbes, not pathogens, may explain the hygiene hypothesis and protective effects against allergy development.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “Horizontal sibling-to- infant transfer of microbes”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN49005404 | collection_date | 2020 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2020 |
| SAMN49005404 | country | IE | R1 | 0.90 | biosample_attr | Ireland: Dublin |
| SAMN49005404 | subject_id | Infant1 | R1 | 0.85 | biosample_attr | Infant1 |
Sequencing
353 runs over 353 samples · mean 9.75 Gbp per run (median 9.86 Gbp, total 3,443.32 Gbp; 353 runs with a base count) · layout PAIRED 353 · platform ILLUMINA 353 · models Illumina NovaSeq 6000 (353) · 94% of runs with a Sandpiper profile · first public 2025-07-03 – 2025-07-27
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1274946.csv.gz (10.6 KB) · parquet (85.4 KB) — all 353 samples, every field with route and confidence · PRJNA1274946_determinations.csv.gz (7.0 KB) — 1,059 evidence rows