FMT trial metagenomics in UK ulcerative colitis adults
166 stool/biopsy samples from UK adults with ulcerative colitis in the STOP-Colitis trial, a randomized open-label pilot comparing nasogastric versus colonic fecal microbiota transplantation. machine-written summary
166 samples · 166 runs · GB · Age unknown · 2025 · 6.46 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,328 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC13012878 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design randomized_controlled_trial · population ulcerative_colitis · Multidose FMT via nasogastric tube vs colonoscopy/enema in ulcerative colitis
“randomized to receive multidose FMT via nasogastric tube or colonoscopy” — abstract:41587946 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolvedFMT donor → recipient — not resolved
Schedule stated by the source: “Fecal samples, colonic mucosal biopsies, and whole blood were collected at baseline and specified follow-up points.” (time origin: intervention start).
FMT trial: 19 donor-recipient pairs (paper); donor stool sequenced (9 donor ids FMT-DON-*); per-recipient donor not published.
Genera, mean relative abundance over 165 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 166 | 100% | ||||
| country | 166 | 100% | 166 | |||
| health_condition | 166 | 100% | 166 | |||
| subject_id | 166 | 100% | 166 | |||
| collection_date | 166 | 100% | 166 | |||
| detailed_location | 166 | 100% | ||||
| health_condition_detail | 166 | 100% | 166 | |||
| latitude | 166 | 100% | 166 | |||
| location_region | 166 | 100% | 166 | |||
| longitude | 166 | 100% | 166 |
- Mechanistic insights into fecal microbiota transplantation for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial. 2026 PMID 41587946 PMC13012878 own_data
Archive description
Short read & long read metagenomic data from the STOP COLITIS trial (ISRCTN74072945)
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.60. Assay shotgun_dna.
- host study.title · “STOP-COLITIS Metagenomic Sequencing Data”
- body site run.scientific_name · “gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN49705501 | collection_date | 2019-01-01 | R1 | 0.90 | biosample.attribute:collection_date | 2019-01-01 |
| SAMN49705501 | country | GB | R1 | 0.90 | sample.attr.geo_loc_name | United Kingdom |
| SAMN49705501 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:alias | FMT-DON-013-D1-1 |
| SAMN49705501 | health_condition_detail | DON | R1 | 0.70 | sample.name_rule:alias | FMT-DON-013-D1-1 |
| SAMN49705501 | latitude | 52.4823 | R1 | 0.90 | biosample.attribute:lat_lon | 52.4823 N 1.8900 W |
| SAMN49705501 | location_region | England | R1 | 0.60 | biosample.attribute:lat_lon | 52.4823 N 1.8900 W |
| SAMN49705501 | longitude | -1.8900 | R1 | 0.90 | biosample.attribute:lat_lon | 52.4823 N 1.8900 W |
| SAMN49705501 | subject_id | FMT-DON-013-D1-1 | R1 | 0.85 | sample.attr.host_subject_id | FMT-DON-013-D1-1 |
Sequencing
166 runs over 166 samples · mean 8.72 Gbp per run (median 6.46 Gbp, total 1,447.11 Gbp; 166 runs with a base count) · layout PAIRED 166 · platform ILLUMINA 166 · models Illumina HiSeq X (166) · 99% of runs with a Sandpiper profile · first public 2025-12-03 – 2025-12-21
Authors (33)
Quraishi MN first · Moakes CA · Yalchin M · Blackwell C · Segal J · Ives NJ · Magill L · Manzoor SE · Gerasimidis K · McMullan C · Mathers J · Horniblow R · Loi S · Kaur M · Loman NJ · Sharma N · Hawkey P · McCune V · Quick J · Nicholls S · McMurray C · Nichols B · Svolos V · Raguideau S · Kerbiriou C · Oo YH · Beggs AD · Crees N · Hansen R · Hart AL · Gaya DR · Quince C · Iqbal TH last
Downloads
PRJNA1283919.csv.gz (5.0 KB) · parquet (77.4 KB) — all 166 samples, every field with route and confidence · PRJNA1283919_determinations.csv.gz (10.6 KB) — 1,328 evidence rows