FMT in Parkinson's with constipation, Shanghai pilot trial
25 fecal/serum samples from Parkinson's disease patients with constipation in Shanghai, China, studied before and after fecal microbiota transplantation (FMT) in a prospective open-label interventional pilot trial. machine-written summary
25 samples · 25 runs · CN · Adult · 2025 · 6.90 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 262 sample values (collection date, country, health condition, health condition detail, intervention, latitude, location locality, location region) |
| ✓ Abstract / description | 2 sample values (health condition, health condition detail) |
| ✓ Full text | 25 sample values (location site) · PMC12790986 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Faecal microbiota transplantation design single_arm_before_after · population neurological_psychiatric · FMT via nasojejunal tube, 3 consecutive days, pilot trial
“fecal microbiota transplantation in patients with constipation” — abstract:41466105 (study level; per-sample arms are in the intervention column below)
longitudinal
5 of 5 people sampled more than once (24 samples; median 5, up to 5 per person) · follow-up median 49 d (max 56 d) · median interval between samples 14 d (time from collection dates). Schedule stated by the source: “stool prior to FMT and at 2, 4, 6, 8 weeks post-FMT” (time origin: transplant); stated follow-up 56 d.
Each row is one person (5 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 25 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 25 | 100% | ||||
| country | 25 | 100% | 25 | |||
| health_condition | 25 | 100% | 24 | 1 | ||
| subject_id | 24 | 96% | 24 | |||
| collection_date | 25 | 100% | 25 | |||
| detailed_location | 25 | 100% | ||||
| health_condition_detail | 25 | 100% | 24 | 1 | ||
| latitude | 25 | 100% | 25 | |||
| location_locality | 25 | 100% | 25 | |||
| location_site | 25 | 100% | 25 | |||
| longitude | 25 | 100% | 25 | |||
| intervention | 24 | 96% | 24 | |||
| timepoint_label | 24 | 96% | 24 | |||
| location_region | 17 | 68% | 17 |
- Pilot Clinical Trial of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease. 2025 PMID 41466105 PMC12790986 own_data
Archive description
Gut dysbacteriosis is closely related to Parkinson's disease. Fecal microbiota transplantation (FMT) has been proposed as an effective way to reconstruct gut microbiota. We launched a clinical study to examine the safety and efficacy of FMT for Parkinson's disease. Five Parkinson's patients with constipation aged 55 to 71 years were enrolled in this prospective open-plabel study. Patients received FMT on 3 consecutive days through nasojejunal tubes and were followed up for 8 weeks after treatment. The UPDRS-III OFF score was used to evaluate the improvement in neurological symptoms, and the Wexner score was used to evaluate the improvement in constipation. We sequenced the microbial communities before and after FMT with shotgun metagenomic sequencing. Fecal and serum samples from patients at the indicated times were subjected to metabolomics for the screening of metabolites. We discovered that FMT improved constipation and neurological symptoms in Parkinson's patients, accompanied by profound alterations within the commensal microbiota. Among them, abundance of Bifidobacterium bifidum, Anaerotruncus colihomini, Acinetobacter sp., Proteobacteria bacterium sp., and uncultured Flavonifractor sp. strains were significantly increased after FMT, while abundance of Acinetobacter sp. and other strains were decreased. Untargeted metabolomics analysis revealed the impacts on amino acid metabolism and unsaturated fatty acid synthesis by FMT in Parkinson's patients. Additionally, integrated analysis hinted the correlation between metabolomic profiles of FMT recipient with specific bacterial strains. Taken together, this pilot study demonstrated the safety and potential of FMT to improve constipation and neurological symptoms in patients with Parkinson's disease.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by opus_adjudicated with confidence 0.85. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.description · “Five Parkinson's patients with constipation”
- body site study.description · “Fecal and serum samples from patients”
- body site run.scientific_name · “gut metagenome”
- life stage study.description · “aged 55 to 71 years”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN49717473 | collection_date | 2019-08-10 | R1 | 0.90 | biosample.attribute:collection_date | 2019-08-10 |
| SAMN49717473 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Shanghai |
| SAMN49717474 | health_condition | neurological_psychiatric | R1 | 0.70 | sample.name_rule:alias | PD0C |
| SAMN49717473 | health_condition | neurological_psychiatric | R4 | 0.50 | study.description | Parkinson's patients with constipation |
| SAMN49717474 | health_condition_detail | PD0C | R1 | 0.70 | sample.name_rule:alias | PD0C |
| SAMN49717473 | health_condition_detail | Parkinson's disease with constipation | R4 | 0.50 | study.description | Parkinson's patients with constipation |
| SAMN49717474 | intervention | fmt | R1 | 0.70 | sample.name_rule:alias | PD0C |
| SAMN49717473 | latitude | 31.3400 | R1 | 0.90 | biosample.attribute:lat_lon | 31.34 N 121.37 E |
| SAMN49717473 | location_locality | Shanghai | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Shanghai |
| SAMN49717473 | location_region | Shanghai Shi | R1 | 0.60 | biosample.attribute:lat_lon | 31.34 N 121.37 E |
| SAMN49717473 | location_site | Huashan Hospital, Fudan University | R3 | 0.70 | paper.fulltext.methods | Ethics Committee of Huashan Hospital, Fudan University |
| SAMN49717473 | longitude | 121.3700 | R1 | 0.90 | biosample.attribute:lat_lon | 31.34 N 121.37 E |
| SAMN49717474 | subject_id | Patient_C | R1 | 0.70 | sample.name_rule:alias | PD0C |
| SAMN49717474 | timepoint_label | week 0 | R1 | 0.70 | sample.name_rule:alias | PD0C |
Sequencing
25 runs over 25 samples · mean 7.04 Gbp per run (median 6.90 Gbp, total 175.94 Gbp; 25 runs with a base count) · layout PAIRED 25 · platform ILLUMINA 25 · models HiSeq X Ten (25) · 100% of runs with a Sandpiper profile · first public 2025-07-02 – 2025-07-06
Downloads
PRJNA1284285.csv.gz (1.9 KB) · parquet (72.6 KB) — all 25 samples, every field with route and confidence · PRJNA1284285_determinations.csv.gz (3.7 KB) — 289 evidence rows