Gut Microbiome in Pediatric Type 1 Diabetes, China
125 gut microbiome samples from China in a case-control study comparing newly diagnosed pediatric Type 1 diabetes patients, stratified by age of onset, with healthy controls. machine-written summary
125 samples · 125 runs · CN · Age unknown · 2025 · 10.04 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 500 sample values (collection date, country, latitude, longitude) |
| ✓ Abstract / description | 125 sample values (health condition detail) |
| ✓ Full text | 250 sample values (antibiotic exposure, subject id) · PMC13042609, PMC13269897 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 125 | 100% | 125 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 125 | 100% | 125 | |||
| antibiotic_exposure | 125 | 100% | 125 | |||
| collection_date | 125 | 100% | 125 | |||
| health_condition_detail | 125 | 100% | 125 | |||
| latitude | 125 | 100% | 125 | |||
| longitude | 125 | 100% | 125 |
- Microbiome-Based Clustering Identifies Glycemic Control-Related Subtypes in Youth With Recent-Onset Type 1 Diabetes. 2026 PMID 41930333 PMC13042609 own_data
- Multi-omics reveals microbiota, metabolite, and immunological heterogeneity of age-related endotypes in type 1 diabetes. 2026 PMID 42297781 PMC13269897 own_data
Archive description
Type 1 diabetes is an autoimmune disease characterized by the destruction of pancreatic cells. Changes in faecal microbiota are associated with Type 1 diabetes. However, it is uncertain whether islet autoimmunity specific gut microbiome differences. We focused on the complex associations among the gut microbiome in T1D patients with immunophenotype.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN49760645 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | antibiotic or probiotic use within the past 3 months |
| SAMN49760645 | collection_date | 2021-01-01/2022-12-31 | R1 | 0.90 | biosample.attribute:collection_date | 2021-01-01/2022-12-31 |
| SAMN49760645 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN49760645 | health_condition_detail | mixed_case_control: T1D patients vs healthy controls | R4 | 0.50 | study.description | Type 1 diabetes is an autoimmune disease |
| SAMN49760645 | latitude | 35.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 35.0 N 105.0 E |
| SAMN49760645 | longitude | 105.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 35.0 N 105.0 E |
| SAMN49760645 | subject_id | SAMN49760645 | R3 | 0.75 | design.one_sample_per_subject:fulltext | the cross-sectional design of this study restricts causal interpretation |
Sequencing
125 runs over 125 samples · mean 9.97 Gbp per run (median 10.04 Gbp, total 1,245.65 Gbp; 125 runs with a base count) · layout PAIRED 125 · platform DNBSEQ 125 · models DNBSEQ-T7 (125) · 0% of runs with a Sandpiper profile · first public 2025-11-01
Authors (14)
Tan H first · Ding Y · Gu Z · Wang X · Wang J · Wei T · Zhang X · Pan L · Shi Y · Chang S · Guo C · Weng J · Zheng X · Yue T last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1285275.csv.gz (4.2 KB) · parquet (76.1 KB) — all 125 samples, every field with route and confidence · PRJNA1285275_determinations.csv.gz (6.8 KB) — 875 evidence rows