Gut microbiome in PLWH on dolutegravir therapy, Sweden
9 samples from people living with HIV in Sweden, studying gut microbiome changes associated with dolutegravir drug therapy and weight gain, using an intervention design. machine-written summary
9 samples · 9 runs · SE · Adult · 2026 · 9.45 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 49 sample values (age, collection date, country, health condition, health condition detail, sex, subject id) |
| ✓ Abstract / description | 10 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design single_arm_before_after · population transplant_or_immunocompromised · Dolutegravir (antiretroviral) treatment in people living with HIV
“Impact of dolutegravir on the gut microbiome” — study.title (study level; per-sample arms are in the intervention column below)
sex differs between samples of the same subject id (1 subjects, 2 samples) — sex withheld; subject ids shared by samples of both sexes (1 ids, 2 samples) — ids withheld.
The sources disagree on 2 samples. Where two incompatible values exist for one sample (or one person's samples disagree on sex), neither value is published: the field is left empty here, in the sample sheet and in the downloads. Both sides, with their sources, are in gut_metadata_contradictions.parquet of the data package (what counts as a contradiction).
Contradicted values (4)
| sample | field | value | other value | handling |
|---|---|---|---|---|
| SAMN50369377 | sex | male (sequence archive) | subject 2: male in 1 sample, female in 1 sample | withheld: neither value published |
| SAMN50369382 | sex | female (sequence archive) | subject 2: male in 1 sample, female in 1 sample | withheld: neither value published |
| SAMN50369377 | subject id | 2 | male (sequence archive) | subject id withheld (samples of both sexes share it) |
| SAMN50369382 | subject id | 2 | female (sequence archive) | subject id withheld (samples of both sexes share it) |
longitudinal
3 of 4 people sampled more than once (6 samples; median 2, up to 2 per person) · follow-up median 21.0 y (max 21.1 y) · median interval between samples 21.0 y (time from age at collection).
Each row is one person (3 shown); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 9 | 100% | ||||
| country | 9 | 100% | 9 | |||
| health_condition | 9 | 100% | 4 | 5 | ||
| subject_id | 7 | 78% | 7 | |||
| age_at_collection_days | 9 | 100% | 9 | |||
| collection_date | 9 | 100% | 9 | |||
| health_condition_detail | 9 | 100% | 4 | 5 | ||
| sex | 7 | 78% | 7 |
Archive description
changes in the Gut microbiome profile affects the weight gain in HIV patients treated with dolutegravir
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by opus_adjudicated with confidence 0.65. Assay shotgun_dna.
- host study.description · “HIV patients treated with dolutegravir”
- body site study.title · “dolutegravir on the gut microbiome”
- life stage sample.attr.age · “46 (n=7/9)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN50369376 | age_at_collection_days | 17872.0 | R1 | 0.85 | sample.attr.age | 49 |
| SAMN50369376 | collection_date | 2021 | R1 | 0.90 | biosample.attribute:collection_date | 2021 |
| SAMN50369376 | country | SE | R1 | 0.90 | sample.attr.geo_loc_name | Sweden |
| SAMN50369381 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:isolate | isolate: Healthy Control |
| SAMN50369376 | health_condition | other_infection | R4 | 0.50 | study.description | HIV patients treated with dolutegravir |
| SAMN50369381 | health_condition_detail | Healthy Control | R1 | 0.85 | biosample.attribute:isolate | isolate: Healthy Control |
| SAMN50369376 | health_condition_detail | People living with HIV (PLWH) | R4 | 0.50 | study.description | HIV patients treated with dolutegravir |
| SAMN50369376 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN50369376 | subject_id | 1 | R1 | 0.70 | sample.name_rule:alias | alias: HF-1 |
Sequencing
9 runs over 9 samples · mean 9.93 Gbp per run (median 9.45 Gbp, total 89.33 Gbp; 9 runs with a base count) · layout PAIRED 9 · platform ILLUMINA 9 · models Illumina NovaSeq 6000 (9) · 0% of runs with a Sandpiper profile · first public 2026-04-19
Authors (0)
No author record.
Downloads
PRJNA1300398.csv.gz (1.3 KB) · parquet (70.3 KB) — all 9 samples, every field with route and confidence · PRJNA1300398_determinations.csv.gz (1.2 KB) — 59 evidence rows