VLBW preterm infant gut microbiome, growth faltering, cohort
517 fecal samples from very low birth weight preterm infants, collected serially from birth to hospital discharge, in a longitudinal cohort study examining whether gut microbiome composition is associated with growth faltering or growth failure. machine-written summary
517 samples · 517 runs · US · Infant / toddler · 2026 · 1.45 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 3,102 sample values (age, collection date, country, sex, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 1,034 sample values (health condition, health condition detail) · PMC13528780 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal
86 of 90 people sampled more than once (513 samples; median 5, up to 14 per person) · follow-up median 44 d (max 3 mo) · median interval between samples 7 d (time from age at collection). Schedule stated by the source: “weekly fecal sampling from birth to hospital discharge” (time origin: birth).
Each row is one person (36 shown of 86); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 517 | 100% | ||||
| country | 517 | 100% | 517 | |||
| health_condition | 517 | 100% | 517 | |||
| subject_id | 517 | 100% | 517 | |||
| age_at_collection_days | 517 | 100% | 517 | |||
| collection_date | 517 | 100% | 517 | |||
| health_condition_detail | 517 | 100% | 517 | |||
| sex | 517 | 100% | 517 | |||
| timepoint_label | 517 | 100% | 517 |
- Gut microbiome in preterm infants with different weight gain outcomes. 2026 PMID 42677317 PMC13528780 own_data
Archive description
Among very low birth weight (VLBW <1500g) infants, failure to gain appropriate weight during hospitalization is associated with adverse outcomes. The gut microbiome contributes to nutrient accretion. Perturbation of the assembly of intestinal microbial communities in term infants has been linked to growth failure. However, if the microbiome modulates growth in preterm infants, and particularly growth faltering, a potentially more clinically relevant marker of malnutrition in preterm infants has not been explored.</p><p>Prospective cohort study of 101 VLBW infants with 855 serial fecal specimens collected from birth to hospital discharge and sequenced using shotgun metagenomics. The stool microbiome was evaluated in infants with growth faltering categorized as a reduction in weight-for-age z scores from birth to 36 weeks PMA: <=0.8 (none), >0.8 to 1.2 (mild) >1.2 (moderate to severe), and in infants with growth failure (<3rd percentile weight-for-age) at 36 weeks PMA. In a subset of 46 infants and 202 samples, fecal metabolomics was performed using 1H NMR-based metabolomics. All analyses were adjusted for postnatal age and birthweight z-score, and additionally with variables for diet and antibiotic exposure as appropriate.</p><p>At 36 weeks PMA, 18% of infants had growth failure, and 53.5% had growth faltering. Both definitions identified distinct populations of infants. Age was associated with significant changes in microbiome composition, gene abundance, and metabolite concentration. When adjusting for postnatal age, infants in the comparator groups did not differ in diversity or taxonomic composition. Microbial genomic composition analysis of the 500 most abundant Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologs (KO) showed that 3 KOs were decreased in mild growth faltering 1 KO was decreased, and 5 KOs were increased in moderate to severe faltering. The glycolysis and gluconeogenesis pathway was decreased in abundance among infants with moderate to severe faltering. No differences in the top 500 KO were found in infants with and without growth failure. Metabolite concentrations were not significantly different in the study groups. Microbiome maturity models identified a lag in maturity among infants with growth failure, but not in infants with growth faltering.</p><p>In contrast to older children with deprivation-related malnutrition, there were minimal differences in microbiome measures in preterm infants with growth faltering or growth failure, except for a delay in microbiome maturity among infants with growth failure.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and neonate and child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “not associated with gut microbiome measures”
- body site study.description · “adverse outcomes. The gut microbiome contributes to”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “Preterm infant weight gain patterns”
- life stage study.title · “Preterm infant weight gain”
- life stage study.description · “modulates growth in preterm infants, and particularly”
- life stage study.description · “contrast to older children with deprivation-related malnutrition,”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN50455251 | age_at_collection_days | 49 | R1 | 0.90 | biosample_attr | 48.77708333333334 |
| SAMN50455251 | collection_date | 2018 | R1 | 0.85 | biosample.attribute:collection_date | 2018 |
| SAMN50455251 | country | US | R1 | 0.90 | biosample_attr | USA |
| SAMN50455251 | health_condition | preterm_nicu | R3 | 0.70 | paper.body.methods | born with birth weight <1500 grams and gestational age <34 weeks |
| SAMN50455251 | health_condition_detail | very low birth weight (VLBW; <1500g) infants, gestational age <34 weeks | R3 | 0.70 | paper.body.methods | born with birth weight <1500 grams and gestational age <34 weeks |
| SAMN50455251 | sex | female | R1 | 0.90 | biosample_attr | female |
| SAMN50455251 | subject_id | 124 | R1 | 0.70 | sample.name_rule:library_name | inf124Cat1T7n1 |
| SAMN50455251 | timepoint_label | 8 | R1 | 0.85 | biosample.attribute:wol | 8 |
Sequencing
517 runs over 517 samples · mean 1.46 Gbp per run (median 1.45 Gbp, total 756.39 Gbp; 517 runs with a base count) · layout PAIRED 517 · platform ILLUMINA 517 · models Illumina HiSeq 2500 (517) · 0% of runs with a Sandpiper profile · first public 2026-03-23
Authors (0)
No author record.
Downloads
PRJNA1301887.csv.gz (16.8 KB) · parquet (92.8 KB) — all 517 samples, every field with route and confidence · PRJNA1301887_determinations.csv.gz (35.3 KB) — 4,136 evidence rows