Infant gut resistome in probiotic trial, Tanzania
250 samples from infants in Tanzania, studying whether probiotic supplementation prevents colonisation by ARG-carrying pathogens and modulates the gut resistome and mobilome, in a randomized trial. machine-written summary
250 samples · 250 runs · TZ · Infant / toddler · 2026 · 41.54 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,000 sample values (collection date, country, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 500 sample values (location site, preterm status) · PMC13198307 |
| ✓ Supplementary tables | 988 sample values (antibiotic exposure, diet, intervention, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population healthy_control · Oral bifidobacteria-based probiotic supplementation for first 4 weeks of life
“Oral probiotics during the first 4 weeks of life” — abstract:42013844 (study level; per-sample arms are in the intervention column below)
longitudinal
98 of 152 people sampled more than once (196 samples; median 2, up to 2 per person) · follow-up median 5 mo (max 5 mo) · median interval between samples 5 mo (time from timepoint labels).
Each row is one person (36 shown of 98); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 250 | 100% | ||||
| country | 250 | 100% | 250 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 250 | 100% | 250 | |||
| collection_date | 250 | 100% | 250 | |||
| detailed_location | 250 | 100% | ||||
| intervention | 250 | 100% | 250 | |||
| location_site | 250 | 100% | 250 | |||
| preterm_status | 250 | 100% | 250 | |||
| sex | 250 | 100% | 250 | |||
| timepoint_label | 250 | 100% | 250 | |||
| diet | 246 | 98% | 246 | |||
| antibiotic_exposure | 242 | 97% | 242 |
- Metabolic reprogramming of the infant gut by bifidobacteria-based probiotics drives exclusion of antibiotic-resistant pathobionts. PMID 42013844 PMC13198307 curated
- Metabolic reprogramming of the infant gut by bifidobacteria-based probiotics drives exclusion of antibiotic-resistant pathobionts curated
Archive description
To investigate whether probiotic supplementation can prevent colonisation by ARG-carrying pathogens and modulate the infant gut resistome and mobilome.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.description · “modulate the infant gut resistome and mobilome.”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “and modulate the infant gut resistome and”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN50600567 | antibiotic_exposure | no | R2 | 0.75 | paper.supp.mmc2.xlsx[Table_S2_Metadata!antibiotics] | no |
| SAMN50600567 | collection_date | 2022-12-15 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2022-12-15 |
| SAMN50600567 | country | TZ | R1 | 0.90 | biosample_attr | Tanzania |
| SAMN50600567 | diet | exclusive_breast_milk | R2 | 0.75 | paper.supp.mmc2.xlsx[Table_S2_Metadata!exclusively_breastfed] | yes |
| SAMN50600567 | intervention | no_intervention | R2 | 0.75 | paper.supp.mmc2.xlsx[Table_S2_Metadata!trial_arm] | Control |
| SAMN50600567 | location_site | Haydom Lutheran Hospital | R3 | 0.70 | paper.fulltext.methods | conducted at Haydom Lutheran Hospital (HLH) and the surrounding area |
| SAMN50600567 | preterm_status | term | R3 | 0.80 | paper.fulltext.abstract | 152 full-term Tanzanian infants enrolled in the ProRIDE trial |
| SAMN50600567 | sex | female | R2 | 0.75 | paper.supp.mmc2.xlsx[Table_S2_Metadata!sex] | female |
| SAMN50600567 | subject_id | A-1361 | R1 | 0.85 | biosample_attr | A-1361 |
| SAMN50600567 | timepoint_label | 6M | R1 | 0.80 | biosample_attr | 6M |
Sequencing
250 runs over 250 samples · mean 42.65 Gbp per run (median 41.54 Gbp, total 10,662.76 Gbp; 250 runs with a base count) · layout PAIRED 250 · platform DNBSEQ 250 · models DNBSEQ-T7 (250) · 0% of runs with a Sandpiper profile · first public 2026-03-22
Authors (10)
Bargheet A first · Bø GH · Hetland MAK · Justine M · Moyo SJ · Löhr IH · Blomberg B · Langeland N · Klingenberg C · Pettersen VK last
Downloads
PRJNA1305341.csv.gz (8.6 KB) · parquet (81.6 KB) — all 250 samples, every field with route and confidence · PRJNA1305341_determinations.csv.gz (12.7 KB) — 2,488 evidence rows