Gut microbiome in FIT samples from CRC screening, Turin
1164 fecal immunochemical test samples from a colorectal cancer screening program in Turin, Italy, collected longitudinally to study gut microbiome feasibility and associations with colorectal cancer. machine-written summary
1,164 samples · 1,164 runs · IT · Age unknown · 2026 · 7.19 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 10,729 sample values (age, antibiotic exposure, bmi, country, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 1,164 | 100% | ||||
| country | 1,164 | 100% | 1,164 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| age_at_collection_days | 1,164 | 100% | 1,164 | |||
| detailed_location | 1,164 | 100% | ||||
| latitude | 1,164 | 100% | 1,164 | |||
| location_locality | 1,164 | 100% | 1,164 | |||
| location_region | 1,164 | 100% | 1,164 | |||
| longitude | 1,164 | 100% | 1,164 | |||
| sex | 1,164 | 100% | 1,164 | |||
| smoking_status | 903 | 78% | 903 | |||
| antibiotic_exposure | 894 | 77% | 894 | |||
| bmi | 784 | 67% | 784 |
- Fecal immunochemical tests from population-based colorectal cancer screening programs support prospective microbiome cohorts. 2026 PMID 42286232 own_data
Archive description
Large, prospective cohort studies with longitudinally collected fecal samples are critically needed to inform the role of the gut microbiome in development of chronic disease and cancer, particularly colorectal cancer (CRC). We evaluated the ability to collect fecal immunochemical tests (FIT) from a CRC screening program in Turin, Italy as well as the efficacy of extraction and sequencing the samples. Overall, our findings recapitulated findings from prior smaller studies of the gut microbiome and CRC and support that CRC screening programs offer opportunities to study the role of the gut microbiome prospectively in carcinogenesis among large, diverse populations.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of elderly and adult by sonnet_x2 with confidence 0.82. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
- body site study.description · “longitudinally collected fecal samples”
- life stage sample.attr.age · “68.4 (n=664/1164)”
- life stage sample.attr.age · “59.7 (n=489/1164)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN50602237 | age_at_collection_days | 24702.4 | R1 | 0.85 | sample.attr.age | 67.7 |
| SAMN50602238 | antibiotic_exposure | no | R1 | 0.90 | biosample_attr | No |
| SAMN50602238 | bmi | 24.3 | R1 | 0.90 | sample.attr.bmi | 24.3 |
| SAMN50602237 | country | IT | R1 | 0.90 | sample.attr.geo_loc_name | Italy: Turin |
| SAMN50602237 | latitude | 45.0700 | R1 | 0.90 | biosample.attribute:lat_lon | 45.07 N 7.69 E |
| SAMN50602237 | location_locality | Turin | R1 | 0.85 | biosample.attribute:geo_loc_name | Italy: Turin |
| SAMN50602237 | location_region | Piedmont | R1 | 0.60 | biosample.attribute:lat_lon | 45.07 N 7.69 E |
| SAMN50602237 | longitude | 7.6900 | R1 | 0.90 | biosample.attribute:lat_lon | 45.07 N 7.69 E |
| SAMN50602237 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN50602238 | smoking_status | current | R1 | 0.90 | biosample.attribute:smoking | Smoker |
Sequencing
1,164 runs over 1,164 samples · mean 7.47 Gbp per run (median 7.19 Gbp, total 8,689.95 Gbp; 1,164 runs with a base count) · layout SINGLE 1,164 · platform BGISEQ 1,164 · models MGISEQ-2000RS (1,164) · 0% of runs with a Sandpiper profile · first public 2026-01-02 – 2026-01-20
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1305379.csv.gz (35.2 KB) · parquet (116.4 KB) — all 1,164 samples, every field with route and confidence · PRJNA1305379_determinations.csv.gz (71.2 KB) — 10,729 evidence rows