Oral-gut microbiome transmission in cohabitants
Paired oral and fecal metagenomic samples (N=176) from household members and romantic partners to study microbial strain transmission between individuals and across body sites. machine-written summary
176 samples · 176 runs · IT · Age unknown · 2026 · 14.19 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,929 sample values (age, country, family id, family role, health condition, health condition detail, sex, shared setting id) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
familieshouseholdsmother–infantparent–childpartners / couplessiblings
47 households/families with ≥2 sampled members (48 family_ids): 24 mothers, 9 fathers, 70 children/siblings; paired oral+gut · 47 families with 102 sampled people (33 with a parent and a child) · 47 shared settings.
motherfatherchildsiblingmember · circles are people (pale = no sequenced sample), arrows run donor → recipient and parent → child, curved lines join twins, partners and siblings, squares are shared settings or families without recorded roles. Shown: 24 of 47 families (one per family structure, then more) · 8 of 47 shared settings. 100 people in the project overall.
Families (25 of 47)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 169 | 96% | ||||
| country | 176 | 100% | 176 | |||
| health_condition | 176 | 100% | 176 | |||
| subject_id | 176 | 100% | 176 | |||
| family_id | 176 | 100% | 176 | |||
| family_role | 176 | 100% | 176 | |||
| health_condition_detail | 176 | 100% | 176 | |||
| sex | 176 | 100% | 176 | |||
| shared_setting_id | 176 | 100% | 176 | |||
| shared_setting_type | 176 | 100% | 176 | |||
| timepoint_label | 176 | 100% | 176 | |||
| age_at_collection_days | 169 | 96% | 169 |
- Strain transmission links human microbiomes along the oral-gut axis and across cohabiting individuals. 2026 PMID 42312244 PMC13269251 unsure
Archive description
Metagenomic cohort of individuals living in the same household, with availability of paired oral and fecal samples. This is used to evaluate oral and gut microbiome transmission in the context of households as well as oral-gut transmission.
How this project entered the registry
Classified as human gut / stool / oral cavity shotgun DNA metagenome of child and adult and adolescent by sonnet_x2 with confidence 0.57. Assay shotgun_dna.
- host study.description · “Metagenomic cohort of individuals living in the same household”
- body site study.description · “paired oral and fecal samples”
- life stage sample.attr.age · “7 (n=71/176)”
- life stage sample.attr.age · “43 (n=62/176)”
- life stage sample.attr.age · “16 (n=34/176)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN50713660 | age_at_collection_days | 21915.0 | R1 | 0.85 | sample.attr.age | 60 |
| SAMN50713660 | country | IT | R1 | 0.90 | sample.attr.geo_loc_name | Italy |
| SAMN50713660 | family_id | family_42 | R1 | 0.85 | biosample.attribute:family_id | family_id: family_42 |
| SAMN50713660 | family_role | mother | R1 | 0.85 | biosample.attribute:participant_type | participant_type: Mother |
| SAMN50713660 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:disease | non_celiac |
| SAMN50713661 | health_condition | autoimmune_inflammatory | R1 | 0.90 | biosample_attr | celiac |
| SAMN50713660 | health_condition_detail | non_celiac | R1 | 0.90 | sample.attr.disease | non_celiac |
| SAMN50713660 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN50713660 | shared_setting_id | family_42 | R1 | 0.85 | biosample.attribute:family_id | family_id: family_42 |
| SAMN50713660 | shared_setting_type | household | R1 | 0.85 | biosample.attribute:family_id | family_id: family_42; project: individuals living in the same household |
| SAMN50713660 | subject_id | M42 | R1 | 0.85 | sample.attr.subjectid | M42 |
| SAMN50713660 | timepoint_label | T01 | R1 | 0.85 | sample.attr.timepoint | T01 |
Sequencing
176 runs over 176 samples · mean 12.58 Gbp per run (median 14.19 Gbp, total 2,214.56 Gbp; 176 runs with a base count) · layout PAIRED 176 · platform ILLUMINA 176 · models Illumina NovaSeq 6000 (176) · 0% of runs with a Sandpiper profile · first public 2026-05-27
Authors (17)
Heidrich V first · Fackelmann G · Ricci L · Spadazzi R · Baldanzi G · Punčochář M · Catassi G · Marchi P · Modesto M · Piccinno G · Porcari S · Rondinella D · Asnicar F · Valles-Colomer M · Mattarelli P · Ianiro G · Segata N last
Downloads
PRJNA1308818.csv.gz (6.9 KB) · parquet (78.7 KB) — all 176 samples, every field with route and confidence · PRJNA1308818_determinations.csv.gz (15.1 KB) — 1,929 evidence rows