LBP vs FMT for recurrent C. difficile infection, USA (NY)
87 gut metagenome samples from New York, USA, from a phase 1b randomized controlled trial comparing an in vitro manufactured live biotherapeutic product (MTC01) to fecal microbiota transplant for recurrent Clostridioides difficile infection. machine-written summary
87 samples · 87 runs · US · Age unknown · 2026 · 8.69 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 768 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 87 sample values (location site) · PMC13444918 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation Defined bacterial consortium / live biotherapeutic product design randomized_controlled_trial · population gi_infection_or_diarrhoea · 15-strain LBP (MTC01) vs same-donor FMT, low/high dose
“low-dose FMT (n = 4)” — abstract:42230754 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
17 of 19 people sampled more than once (78 samples; median 5, up to 5 per person). Schedule stated by the source: “SCRN (screening), then WK1, WK8, WK12, WK26 post-dosing per subject” (time origin: intervention_start).
Genera, mean relative abundance over 68 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 87 | 100% | ||||
| country | 87 | 100% | 87 | |||
| health_condition | 87 | 100% | 87 | |||
| subject_id | 80 | 92% | 80 | |||
| collection_date | 87 | 100% | 87 | |||
| detailed_location | 87 | 100% | ||||
| health_condition_detail | 87 | 100% | 87 | |||
| latitude | 87 | 100% | 87 | |||
| location_region | 87 | 100% | 87 | |||
| location_site | 87 | 100% | 87 | |||
| longitude | 87 | 100% | 87 | |||
| timepoint_label | 79 | 91% | 79 |
- 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial. 2026 PMID 42230754 PMC13444918 own_data
Archive description
Live biotherapeutic product exhibits similar efficacy and engraftment to same donor fecal microbiota transplant for recurrent Clostridioides difficile infection
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.description · “fecal microbiota transplant”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54558448 | collection_date | 2024-12 | R1 | 0.90 | biosample.attribute:collection_date | 2024-12 |
| SAMN54558448 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA:NY |
| SAMN54558448 | health_condition | gi_infection_or_diarrhoea | R1 | 0.90 | biosample_attr | rCDI (C. difficile) |
| SAMN54558448 | health_condition_detail | rCDI (C. difficile) | R1 | 0.90 | sample.attr.host_disease | rCDI (C. difficile) |
| SAMN54558448 | latitude | 40.7128 | R1 | 0.90 | biosample.attribute:lat_lon | 40.7128 N 74.0060 W |
| SAMN54558448 | location_region | New York | R1 | 0.75 | biosample.attribute:geo_loc_name | USA:NY |
| SAMN54558448 | location_site | Mount Sinai Hospital | R3 | 0.70 | paper.fulltext.methods | Patients were consented at Mount Sinai Hospital under IRB |
| SAMN54558448 | longitude | -74.0060 | R1 | 0.90 | biosample.attribute:lat_lon | 40.7128 N 74.0060 W |
| SAMN54558455 | subject_id | LBP-001 | R1 | 0.70 | sample.name_rule:alias | LBP-001-SCRN |
| SAMN54558455 | timepoint_label | SCRN | R1 | 0.70 | sample.name_rule:alias | LBP-001-SCRN |
Sequencing
87 runs over 87 samples · mean 9.01 Gbp per run (median 8.69 Gbp, total 783.87 Gbp; 87 runs with a base count) · layout PAIRED 87 · platform ILLUMINA 87 · models Illumina NovaSeq X (87) · 78% of runs with a Sandpiper profile · first public 2026-01-11
Authors (16)
Bethlehem L first · Bartu L · Marke G · Mar P · Feldman S · Eggers J · Ruprecht C · Britton GJ · Aggarwala V · Bongers G · Li Z · Yang N · Hohmann EL · Mogno I · Faith JJ · Grinspan A last
Downloads
PRJNA1322507.csv.gz (3.2 KB) · parquet (74.0 KB) — all 87 samples, every field with route and confidence · PRJNA1322507_determinations.csv.gz (6.5 KB) — 855 evidence rows