Azithromycin MDA & gut/nasopharyngeal resistome, Niger
450 samples from a cluster-randomized trial in Niger evaluating how twice-yearly mass azithromycin distribution to preschool children affects antibiotic resistance in the gut and nasopharyngeal microbiome. machine-written summary
450 samples · 450 runs · NE · Child · 2026 · 1.71 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 450 sample values (country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 450 sample values (collection date) · PMC13004693 |
| ✓ Supplementary tables | 900 sample values (sex, subject id) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Antibiotic given as the study intervention (incl. eradication therapy design randomized_controlled_trial · Azithromycin mass drug administration vs placebo, semiannual, 2 years
“cluster-randomized, placebo-controlled trial” — abstract:41845058 (study level; per-sample arms are in the intervention column below)
community — not resolved
150 village-pooled rectal swab samples (~30 children per village pooled; one gut pool per village, AVENIR cluster-randomized MDA trial).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 450 | 100% | 450 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 450 | 100% | 450 | |||
| collection_date | 450 | 100% | 450 | |||
| sex | 450 | 100% | 450 |
- Mass azithromycin distribution and antibiotic resistance in the gut and nasopharynx: a cluster-randomized trial. PMID 41845058 PMC13004693 curated
Archive description
Repeated twice-yearly azithromycin mass drug distribution (MDA) to preschool children reduced all-cause childhood mortality. However, the potential selection of antibiotic resistance (AMR) is a major public health concern as the program is being implemented in multiple countries in sub-Saharan Africa. This study evaluated the impact of azithromycin MDA targeting different age groups on the gut and nasopharyngeal microbiome and resistome of children in participating communities.
How this project entered the registry
Classified as human gut / stool / nasal / nasopharyngeal mixed assays of child and infant / toddler by sonnet_x2 with confidence 0.68. Assay mixed.
- host run.host_tax_id · “9606”
- body site study.title · “Gut and Nasopharynx”
- life stage study.description · “azithromycin MDA targeting different age groups”
- life stage study.description · “mass drug distribution (MDA) to preschool children”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN52233313 | collection_date | 2023-05/2023-11 | R3 | 0.70 | paper.fulltext.methods | started on 20 May 2023 and ended on 23 November 2023 |
| SAMN52233313 | country | NE | R1 | 0.90 | biosample_attr | Niger |
| SAMN52233313 | sex | male | R2 | 0.75 | paper.supp.table | sex=Male |
| SAMN52233313 | subject_id | child_1106 | R2 | 0.75 | paper.supp.table | child_id=child_1106 |
Sequencing
450 runs over 450 samples · mean 1.82 Gbp per run (median 1.71 Gbp, total 818.57 Gbp; 450 runs with a base count) · layout PAIRED 450 · platform ILLUMINA 450 · models Illumina NovaSeq X Plus (450) · 0% of runs with a Sandpiper profile · first public 2026-04-02
Authors (28)
Doan T first · Yan D · Arzika AM · Abdou A · Maliki R · Aichatou B · Bello IM · Beidi D · Galo N · Harouna N · Karamba AM · Mahamadou S · Abarchi M · Ibrahim A · Zhong L · Chen C · Liu Y · Yu D · Abraham T · Cheng AS · Peterson B · Oldenburg CE · Porco TC · Arnold BF · Hinterwirth A · Lebas E · O'Brien KS · Lietman TM last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1337442.csv.gz (13.5 KB) · parquet (88.1 KB) — all 450 samples, every field with route and confidence · PRJNA1337442_determinations.csv.gz (10.8 KB) — 1,800 evidence rows