Gut microbiota in insomnia: a case-control metagenomic study
114 adult gut metagenome samples from a case-control study comparing primary insomnia, post-COVID insomnia, and controls, examining associations between gut microbiota and insomnia. machine-written summary
114 samples · 114 runs · HK · Adult · 2026 · 6.28 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 570 sample values (collection date, country, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 228 sample values (antibiotic exposure, location locality) · PMC13589507 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 57 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 114 | 100% | ||||
| country | 114 | 100% | 114 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 114 | 100% | 114 | |||
| collection_date | 114 | 100% | 114 | |||
| detailed_location | 114 | 100% | ||||
| latitude | 114 | 100% | 114 | |||
| location_locality | 114 | 100% | 114 | |||
| location_region | 114 | 100% | 114 | |||
| longitude | 114 | 100% | 114 |
- Faecalibacterium prausnitzii-derived L-arginine ameliorates insomnia by inhibiting POMC-ACTH-cortisol axis. 2026 PMID 42624113 PMC13589507 own_data
Archive description
Insomnia is associated with gut microbial dysbiosis, but the specific microbial metabolites mediating gut-brain communication remain elusive. Here, we integrate metagenomic sequencing from 171 individuals (primary insomnia, post-COVID insomnia, and controls) with functional pathway analysis and preclinical validation.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “The associations of gut microbiota with insomnia”
- body site study.description · “is associated with gut microbial dysbiosis, but”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54625675 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | antibiotics, probiotics, or prebiotics within 4 weeks prior |
| SAMN54625675 | collection_date | 2023-01-01 | R1 | 0.90 | biosample.attribute:collection_date | 2023-01-01 |
| SAMN54625675 | country | HK | R1 | 0.90 | sample.attr.geo_loc_name | Hong Kong |
| SAMN54625675 | latitude | 22.3828 | R1 | 0.90 | biosample.attribute:lat_lon | 22.3828 N 114.1986 E |
| SAMN54625675 | location_locality | Hong Kong | R3 | 0.70 | paper.fulltext.methods | recruited from sleep clinics and the community in Hong Kong |
| SAMN54625675 | location_region | Sha Tin | R1 | 0.60 | biosample.attribute:lat_lon | 22.3828 N 114.1986 E |
| SAMN54625675 | longitude | 114.1986 | R1 | 0.90 | biosample.attribute:lat_lon | 22.3828 N 114.1986 E |
Sequencing
114 runs over 114 samples · mean 6.73 Gbp per run (median 6.28 Gbp, total 767.41 Gbp; 114 runs with a base count) · layout PAIRED 114 · platform ILLUMINA 114 · models Illumina NovaSeq 6000 (114) · 50% of runs with a Sandpiper profile · first public 2026-01-16 – 2026-09-03
Authors (15)
Wang Y first · Xie S · Li C · Huang R · Zheng Z · Chen S · Wu Y · Zhang H · Yang R · Chan YL · Sun Y · Chan FKL · Chan NY · Ng SC · Su Q last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1356335.csv.gz (3.9 KB) · parquet (74.8 KB) — all 114 samples, every field with route and confidence · PRJNA1356335_determinations.csv.gz (5.3 KB) — 798 evidence rows