Gut phageome and host metabolism in UK twins
Cross-sectional study of 2,472 stool samples from TwinsUK participants (United Kingdom), characterizing the gut bacteriophage community and its links to host metabolism, including BMI and lipid traits. machine-written summary
2,472 samples · 2,472 runs · GB · Age unknown · 2025 · 3.02 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 12,360 sample values (collection date, country, latitude, longitude, subject id) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolvedtwins — not resolved
742 of 1,076 people sampled more than once (2,138 samples; median 2, up to 7 per person).
TwinsUK cohort; 1,076 participants, 2,472 samples; twin pair structure implied by cohort name, no explicit dyad IDs in metadata..
Genera, mean relative abundance over 2,385 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 2,472 | 100% | 2,472 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 2,472 | 100% | 2,472 | |||
| collection_date | 2,472 | 100% | 2,472 | |||
| latitude | 2,472 | 100% | 2,472 | |||
| longitude | 2,472 | 100% | 2,472 |
Archive description
Bacteriophages, viruses that infect bacteria, are emerging as key regulators of the gut microbiome, yet their role in human health remains unclear. Using shotgun metagenomic data from 1,076 TwinsUK participants, we assembled 138,789 non-redundant viral contigs, of which 62% were temperate and 18% virulent. Individuals carried on average 8,545 contigs forming structured networks with bacteria such as Faecalibacterium prausnitzii and Blautia wexlerae. Phageome diversity was mainly shaped by environmental factors with modest heritability. Over 1,000 contigs were linked to BMI and lipid metabolism, many carrying auxiliary metabolic genes, suggesting phage-driven modulation of bacterial metabolism. These findings reveal complex phage bacteria host interactions with potential metabolic and therapeutic implications.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.85. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.description · “1,076 TwinsUK participants”
- body site study.title · “stool microbiomes”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53079104 | collection_date | 2017-01-04 | R1 | 0.90 | biosample.attribute:collection_date | 2017-01-04 |
| SAMN53079104 | country | GB | R1 | 0.90 | sample.attr.geo_loc_name | United Kingdom |
| SAMN53079104 | latitude | 55.3781 | R1 | 0.90 | biosample.attribute:lat_lon | 55.3781 N 3.4360 W |
| SAMN53079104 | longitude | -3.4360 | R1 | 0.90 | biosample.attribute:lat_lon | 55.3781 N 3.4360 W |
| SAMN53079104 | subject_id | 103667-001-004 | R1 | 0.70 | sample.name_rule:TITLE | 103667-001-004 |
Sequencing
2,472 runs over 2,472 samples · mean 4.10 Gbp per run (median 3.02 Gbp, total 10,130.58 Gbp; 2,472 runs with a base count) · layout PAIRED 2,472 · platform ILLUMINA 2,472 · models Illumina HiSeq 2000 (2,472) · 96% of runs with a Sandpiper profile · first public 2025-11-11 – 2025-11-23
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1357304.csv.gz (58.6 KB) · parquet (162.6 KB) — all 2,472 samples, every field with route and confidence · PRJNA1357304_determinations.csv.gz (92.5 KB) — 12,360 evidence rows