Preterm infant gut microbiome, antibiotic exposure
361 samples from preterm infants in Cincinnati, Ohio, USA, studying the impact of antibiotics on gut microbiome maturation. Design not specified. machine-written summary
361 samples · 361 runs · US · Infant / toddler · 2025 · 3.15 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 722 sample values (country, subject id) |
| ✓ Abstract / description | 361 sample values (preterm status) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure · Antibiotic exposure in preterm infants, effect on microbiome maturation
longitudinal — not resolved
67 of 68 people sampled more than once (360 samples; median 6, up to 6 per person).
Genera, mean relative abundance over 351 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 361 | 100% | ||||
| country | 361 | 100% | 361 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 361 | 100% | 361 | |||
| preterm_status | 361 | 100% | 361 |
Archive description
Antibiotic impact on preterm infant microbiome maturation
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and neonate by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “impact on preterm infant microbiome maturation”
- life stage study.title · “Antibiotic impact on preterm infant microbiome maturation”
- life stage study.description · “Antibiotic impact on preterm infant microbiome maturation”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53250519 | country | US | R1 | 0.90 | biosample_attr | USA: Ohio, Cincinnati |
| SAMN53250519 | preterm_status | preterm | R4 | 0.50 | study.title | preterm infant microbiome maturation |
| SAMN53250519 | subject_id | 01 | R1 | 0.70 | sample.name_rule:library_name | N01_1_2 |
Sequencing
361 runs over 361 samples · mean 3.58 Gbp per run (median 3.15 Gbp, total 1,291.93 Gbp; 361 runs with a base count) · layout PAIRED 360, SINGLE 1 · platform ILLUMINA 361 · models Illumina NovaSeq 6000 (361) · 99% of runs with a Sandpiper profile · first public 2025-12-26 – 2025-12-30
Downloads
PRJNA1364313.csv.gz (9.6 KB) · parquet (83.2 KB) — all 361 samples, every field with route and confidence · PRJNA1364313_determinations.csv.gz (6.1 KB) — 1,083 evidence rows