Gut microbiome in tuberculosis patients vs healthy adults
10 adult fecal samples from a case-control study comparing gut microbiome composition in tuberculosis patients and healthy controls, examining ecological guilds (enterosignatures) and metabolic pathway potential. machine-written summary
10 samples · 10 runs · RU · Adult · 2026 · 5.97 Gbp / sample · cohort Bifidobacterium- and Escherichia-dominant ecologic
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 81 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC13433188 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 10 | 100% | ||||
| country | 10 | 100% | 10 | |||
| health_condition | 10 | 100% | 10 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 10 | 100% | 10 | |||
| detailed_location | 10 | 100% | ||||
| health_condition_detail | 10 | 100% | 10 | |||
| latitude | 10 | 100% | 10 | |||
| location_locality | 10 | 100% | 10 | |||
| longitude | 10 | 100% | 10 | |||
| sex | 10 | 100% | 10 | |||
| location_region | 1 | 10% | 1 |
- Bifidobacterium- and Escherichia-dominant ecological guilds shape altered microbial metabolic capacity of the gut microbiome in tuberculosis patients. 2026 PMID 42553090 PMC13433188 own_data
Archive description
This study characterizes the gut microbiome composition and functional potential in treatment-naive tuberculosis (TB) patients prior to chemotherapy initiation, as well as in TB patients after treatment. Using deep metagenomic sequencing of fecal samples from drug-naive TB patients and patients who completed anti-TB therapy, we reconstructed the metabolic capacity and strain-level diversity of the intestinal microbial community. These findings establish a fundamental baseline of the gut microbiome in tuberculosis patients and provide data for understanding how anti-TB chemotherapy alters the gut ecosystem, potentially informing personalized treatment approaches.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Bifidobacterium- and Escherichia-dominated gut microbiome metabolic shifts”
- body site study.description · “study characterizes the gut microbiome composition and”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53315823 | collection_date | 2019-10-21 | R1 | 0.90 | biosample.attribute:collection_date | 2019-10-21 |
| SAMN53315823 | country | RU | R1 | 0.90 | sample.attr.geo_loc_name | Russia: Ufa |
| SAMN53315823 | health_condition | other_infection | R1 | 0.85 | biosample_attr | tuberculosis |
| SAMN53315823 | health_condition_detail | tuberculosis | R1 | 0.90 | sample.attr.host_disease | tuberculosis |
| SAMN53315823 | latitude | 54.7337 | R1 | 0.90 | biosample.attribute:lat_lon | 54.733742 N 55.961797 E |
| SAMN53315823 | location_locality | Ufa | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Ufa |
| SAMN53315823 | location_region | Bashkortostan | R1 | 0.60 | biosample.attribute:lat_lon | 54.733742 N 55.961797 E |
| SAMN53315823 | longitude | 55.9618 | R1 | 0.90 | biosample.attribute:lat_lon | 54.733742 N 55.961797 E |
| SAMN53315823 | sex | female | R1 | 0.90 | sample.attr.host_sex | female |
Sequencing
10 runs over 10 samples · mean 6.00 Gbp per run (median 5.97 Gbp, total 60.00 Gbp; 10 runs with a base count) · layout PAIRED 10 · platform ILLUMINA 10 · models Illumina NovaSeq 6000 (10) · 0% of runs with a Sandpiper profile · first public 2026-05-02
Authors (8)
Yunusbaeva M first · Sabirova D · Borodina L · Khasanova K · Yunusbayeva A · Altinbaev R · Ganiev I · Yunusbayev B last
Downloads
PRJNA1366497.csv.gz (1.2 KB) · parquet (70.3 KB) — all 10 samples, every field with route and confidence · PRJNA1366497_determinations.csv.gz (1.1 KB) — 81 evidence rows