Riboflavin and gut microbiome in elderly, Cork
1032 samples from healthy older adults in Cork, Ireland, studying whether colon-delivered vitamin B2 (riboflavin) alters gut microbiome composition and function; dietary supplement intervention study. machine-written summary
1,032 samples · 1,032 runs · IE · Elderly · 2026 · 8.85 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 7,911 sample values (collection date, country, health condition, health condition detail, intervention, location region, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-microbial dietary supplement (vitamins design single_arm_before_after · population healthy_control · Colon-targeted (delayed-release) vitamin B2/riboflavin supplement
“Colon-delivered vitamin B2” — study.title (study level; per-sample arms are in the intervention column below)
longitudinal
344 of 344 people sampled more than once (1,032 samples; median 3, up to 3 per person) · follow-up median 3 mo (max 4 mo) · median interval between samples 40 d (time from collection dates).
Each row is one person (36 shown of 344); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 1,006 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 1,032 | 100% | ||||
| country | 1,032 | 100% | 1,032 | |||
| health_condition | 1,032 | 100% | 1,032 | |||
| subject_id | 1,032 | 100% | 1,032 | |||
| detailed_location | 1,032 | 100% | ||||
| health_condition_detail | 1,032 | 100% | 1,032 | |||
| location_region | 1,032 | 100% | 1,032 | |||
| timepoint_label | 1,032 | 100% | 1,032 | |||
| collection_date | 1,031 | 100% | 1,031 | |||
| intervention | 688 | 67% | 688 |
- Colon-delivered vitamin B2 as a functional modulator of the human gut microbiome 2026 own_data
Archive description
Vitamin B2 (riboflavin) is a key redox cofactor that may modulate gut microbial ecology, yet conventional supplements are absorbed proximally and have limited colonic exposure. We evaluated whether colon-targeted riboflavin alters microbiome composition, function and network structure as well as host biomarkers in healthy older adults.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by opus_adjudicated with confidence 0.65. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.description · “healthy older adults”
- body site study.title · “the human gut microbiome”
- life stage study.description · “healthy older adults”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54991199 | collection_date | 2023-07-11 | R1 | 0.90 | biosample.attribute:collection_date | 2023-07-11 |
| SAMN54991199 | country | IE | R1 | 0.90 | sample.attr.geo_loc_name | Ireland:Cork |
| SAMN54991199 | health_condition | healthy_control | R1 | 0.70 | biosample.name_rule:TITLE | Placebo_week 12 |
| SAMN54991199 | health_condition_detail | healthy older adults (project description) | R1 | 0.70 | biosample.name_rule:TITLE | Placebo_week 12 |
| SAMN54991199 | intervention | placebo | R1 | 0.70 | biosample.name_rule:TITLE | Placebo_week 12 |
| SAMN54991199 | location_region | Cork | R1 | 0.85 | biosample.attribute:geo_loc_name | Ireland:Cork |
| SAMN54991199 | subject_id | AFCRO-131-257 | R1 | 0.70 | biosample.name_rule:library_id | AFCRO-131-257_visit3_108592-A05 |
| SAMN54991199 | timepoint_label | week 12 | R1 | 0.70 | biosample.name_rule:TITLE | Placebo_week 12 |
Sequencing
1,032 runs over 1,032 samples · mean 8.99 Gbp per run (median 8.85 Gbp, total 9,280.36 Gbp; 1,032 runs with a base count) · layout PAIRED 1,032 · platform ILLUMINA 1,032 · models Illumina NovaSeq 6000 (1,032) · 97% of runs with a Sandpiper profile · first public 2026-02-10 – 2026-02-11
Authors (0)
No author record.
Downloads
PRJNA1370810.csv.gz (28.4 KB) · parquet (109.6 KB) — all 1,032 samples, every field with route and confidence · PRJNA1370810_determinations.csv.gz (73.1 KB) — 7,911 evidence rows