Gut microbiome in chronic liver disease, UK, cross-sectional
Cross-sectional study of 76 gut microbiome samples from adults in the United Kingdom, comparing healthy controls, stable cirrhotic, decompensated cirrhotic, and acute-on-chronic liver failure cohorts using long-read metagenomics. machine-written summary
76 samples · 76 runs · GB · Adult · 2026 · 0.53 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 396 sample values (collection date, country, health condition, health condition detail, latitude, longitude) |
| ✓ Abstract / description | 104 sample values (health condition detail, subject id) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 76 | 100% | ||||
| country | 76 | 100% | 76 | |||
| health_condition | 48 | 63% | 48 | |||
| subject_id | 76 | 100% | 76 | |||
| health_condition_detail | 76 | 100% | 48 | 28 | ||
| latitude | 76 | 100% | 76 | |||
| longitude | 76 | 100% | 76 | |||
| collection_date | 72 | 95% | 72 |
- Decoding the microbiome and resistome of advanced chronic liver disease through long-read metagenomics 2025 own_data
Archive description
Cross-sectional study of the microbial composition and resistance profiles of the gut microbiome of individuals with liver disease. The project was made of four cohorts: healthy controls, stable cirrhotic, decompensated cirrhotic and acute-on-chronic liver failure.
How this project entered the registry
Classified as human blood / tissue / internal fluids / gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “of advanced chronic liver disease through long-read”
- body site study.description · “of individuals with liver disease. The project”
- body site study.description · “profiles of the gut microbiome of individuals”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53796459 | collection_date | 2013 | R1 | 0.90 | biosample.attribute:collection_date | 2013 |
| SAMN53796459 | country | GB | R1 | 0.90 | sample.attr.geo_loc_name | United Kingdom |
| SAMN53796459 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:alias | Healthy_Control1 |
| SAMN53796459 | health_condition_detail | Healthy_Control | R1 | 0.70 | sample.name_rule:alias | Healthy_Control1 |
| SAMN53796507 | health_condition_detail | mixed_case_control: healthy controls vs stable cirrhotic vs decompensated cirrhotic vs acute-on-chronic liver failure | R4 | 0.50 | study.description | healthy controls, stable cirrhotic, decompensated cirrhotic and acute-on-chronic liver failure |
| SAMN53796459 | latitude | 55.3781 | R1 | 0.90 | biosample.attribute:lat_lon | 55.3781 N 3.4360 W |
| SAMN53796459 | longitude | -3.4360 | R1 | 0.90 | biosample.attribute:lat_lon | 55.3781 N 3.4360 W |
| SAMN53796459 | subject_id | SAMN53796459 | R4 | 0.65 | design.one_sample_per_subject:description | Cross-sectional study of the microbial composition and resistance profiles of the gut microbiome of individuals with liver disease |
Sequencing
76 runs over 76 samples · mean 0.62 Gbp per run (median 0.53 Gbp, total 46.91 Gbp; 76 runs with a base count) · layout SINGLE 76 · platform OXFORD_NANOPORE 76 · models GridION (76) · 0% of runs with a Sandpiper profile · first public 2026-06-28
Authors (0)
No author record.
Downloads
PRJNA1377628.csv.gz (2.9 KB) · parquet (73.8 KB) — all 76 samples, every field with route and confidence · PRJNA1377628_determinations.csv.gz (4.2 KB) — 500 evidence rows