Probiotic vs placebo in type 2 diabetes, Szczecin, Poland
70 gut metagenome samples from type 2 diabetes patients in Szczecin, Poland, from an intervention trial of a multi-strain probiotic (vs placebo) alongside metformin, comparing baseline and 12-week timepoints. machine-written summary
70 samples · 70 runs · PL · Age unknown · 2025 · 0.16 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 560 sample values (country, intervention, intervention detail, latitude, location locality, location region, longitude, subject id) |
| ✓ Abstract / description | 140 sample values (health condition, health condition detail) |
| ○ Full text | read; no usable statement or table · PMC12991998 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population type2_diabetes · Multi-strain probiotic 12 weeks vs placebo, with metformin
“12 weeks of probiotic or placebo supplementation” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
35 of 35 people sampled more than once (70 samples; median 2, up to 2 per person). Schedule stated by the source: “Two timepoints: baseline (Visit 2, V2) and end of 12-week treatment period (probiotic or placebo alongside metformin)” (time origin: intervention/treatment start); stated follow-up 3 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 70 | 100% | 70 | |||
| health_condition | 70 | 100% | 70 | |||
| subject_id | 70 | 100% | 70 | |||
| detailed_location | 70 | 100% | ||||
| health_condition_detail | 70 | 100% | 70 | |||
| latitude | 70 | 100% | 70 | |||
| location_locality | 70 | 100% | 70 | |||
| location_region | 70 | 100% | 70 | |||
| longitude | 70 | 100% | 70 | |||
| timepoint_label | 70 | 100% | 70 | |||
| intervention | 35 | 50% | 35 | |||
| intervention_detail | 35 | 50% | 35 |
- Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial) 2026 own_data
- Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial. 2026 PMID 41852479 PMC12991998 own_data
- Multi-strain probiotic enhances metformin tolerance by modulating gut microbiome and bile acid pathways: Insight from multi-omics post-hoc analysis (ProGasMet trial). 2026 PMID 41985330 own_data
Archive description
First 12week treatment period and considered only two timepoints: baseline (Visit 2, V2) and the end of the initial treatment period after 12 weeks of probiotic or placebo supplementation. Shotgun 2x151bp Illumina MiSeq sequences
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.70. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human feces metagenome”
- body site study.title · “modulating gut microbiome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53840740 | country | PL | R1 | 0.90 | sample.attr.geo_loc_name | Poland: Szczecin |
| SAMN53840740 | health_condition | type2_diabetes | R4 | 0.50 | study.description | probiotic or placebo supplementation |
| SAMN53840740 | health_condition_detail | Multi-strain probiotic vs placebo supplementation trial | R4 | 0.50 | study.title | Multi-strain probiotic enhances metformin tolerance |
| SAMN53840740 | intervention | no_intervention | R1 | 0.80 | biosample.attribute:timepoint | timepoint: K1 |
| SAMN53840740 | intervention_detail | baseline visit (Visit 2) | R1 | 0.80 | biosample.attribute:timepoint | timepoint: K1 |
| SAMN53840740 | latitude | 53.4200 | R1 | 0.90 | biosample.attribute:lat_lon | 53.42 N 14.55 E |
| SAMN53840740 | location_locality | Szczecin | R1 | 0.85 | biosample.attribute:geo_loc_name | Poland: Szczecin |
| SAMN53840740 | location_region | West Pomeranian Voivodeship | R1 | 0.60 | biosample.attribute:lat_lon | 53.42 N 14.55 E |
| SAMN53840740 | longitude | 14.5500 | R1 | 0.90 | biosample.attribute:lat_lon | 53.42 N 14.55 E |
| SAMN53840740 | subject_id | 10 | R1 | 0.85 | sample.attr.hostid | 10 |
| SAMN53840740 | timepoint_label | K1 | R1 | 0.85 | sample.attr.timepoint | K1 |
Sequencing
70 runs over 70 samples · mean 0.17 Gbp per run (median 0.16 Gbp, total 11.59 Gbp; 70 runs with a base count) · layout PAIRED 70 · platform ILLUMINA 70 · models Illumina MiSeq (70) · 0% of runs with a Sandpiper profile · first public 2025-12-11
Authors (0)
No author record.
Downloads
PRJNA1378533.csv.gz (2.7 KB) · parquet (73.8 KB) — all 70 samples, every field with route and confidence · PRJNA1378533_determinations.csv.gz (5.2 KB) — 700 evidence rows