Glucuronidome Mapping in Mouse and Human Samples, USA
4 samples from infants in the USA, studying glucuronidated metabolites (the glucuronidome) via untargeted LC-MS/MS metabolomics; no specific health condition or intervention stated; design categorized as other. machine-written summary
4 samples · 4 runs · US · Infant / toddler · 2025 · 1.99 Gbp / sample · cohort Glucuronidation metabolomic fingerprinting to map
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 40 sample values (age, collection date, country, diet, diet detail, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 3 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 4 | 100% | ||||
| country | 4 | 100% | 4 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 4 | 100% | 4 | |||
| age_at_collection_days | 4 | 100% | 4 | |||
| collection_date | 4 | 100% | 4 | |||
| detailed_location | 4 | 100% | ||||
| diet | 4 | 100% | 4 | |||
| diet_detail | 4 | 100% | 4 | |||
| latitude | 4 | 100% | 4 | |||
| location_region | 4 | 100% | 4 | |||
| longitude | 4 | 100% | 4 | |||
| timepoint_label | 4 | 100% | 4 |
- Glucuronidation metabolomic fingerprinting to map host-microbe metabolism. 2026 PMID 42161945 PMC13381908 unsure
Archive description
In this study, we employed pattern-filtering data science approaches in conjunction with untargeted LC-MS/MS metabolomics to map the glucuronidome in urine, serum, and colon/fecal samples from gnotobiotic and conventional mice, and in humans. We find that microbial colonization and GUS activity compress the colonic glucuronidome and expand urinary glucuronidome diversity, revealing a compartmental redistribution of glucuronidated metabolites.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler by opus_adjudicated with confidence 0.60. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- host run.host_tax_id · “9606”
- body site study.description · “colon/fecal samples”
- life stage sample.attr.host_age · “1M (n=4/4)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53864764 | age_at_collection_days | 30.0 | R1 | 0.90 | sample.attr.host_age | 1M |
| SAMN53864764 | collection_date | 2016 | R1 | 0.90 | biosample.attribute:collection_date | 2016 |
| SAMN53864764 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA |
| SAMN53864764 | diet | other_diet | R1 | 0.85 | biosample.attribute:feeding_type;feeding_type_at_one_month | feeding_type: mixed | feeding_type_at_one_month: mixed |
| SAMN53864764 | diet_detail | mixed feeding | R1 | 0.85 | biosample.attribute:feeding_type;feeding_type_at_one_month | feeding_type: mixed | feeding_type_at_one_month: mixed |
| SAMN53864764 | latitude | 39.9560 | R1 | 0.90 | biosample.attribute:lat_lon | 39.956 N 75.193 W |
| SAMN53864764 | location_region | Pennsylvania | R1 | 0.60 | biosample.attribute:lat_lon | 39.956 N 75.193 W |
| SAMN53864764 | longitude | -75.1930 | R1 | 0.90 | biosample.attribute:lat_lon | 39.956 N 75.193 W |
| SAMN53864764 | subject_id | 115-2 | R1 | 0.85 | sample.attr.pid | 115-2 |
| SAMN53864764 | timepoint_label | 115-1M | R1 | 0.85 | biosample.attribute:study_id_visit | study_id_visit: 115-1M |
Sequencing
4 runs over 4 samples · mean 1.92 Gbp per run (median 1.99 Gbp, total 7.69 Gbp; 4 runs with a base count) · layout PAIRED 4 · platform ILLUMINA 4 · models Illumina HiSeq 2500 (4) · 75% of runs with a Sandpiper profile · first public 2025-12-21
Authors (24)
Boyle NR first · Sekela JJ · Wang M · Mannochio-Russo H · Pyo JJ · Kim MS · Tian S · Koo I · Friedman ES · Tanes C · Anitha M · Tian Y · Morgan EW · Murray IA · Zackular JP · Bittinger K · Lewis JD · Perdew GH · Wu GD · Zemel BS · Dorrestein PC · Bisanz JE · Redinbo MR · Patterson AD last
Downloads
PRJNA1379156.csv.gz (1.0 KB) · parquet (70.4 KB) — all 4 samples, every field with route and confidence · PRJNA1379156_determinations.csv.gz (1012 B) — 40 evidence rows