Healthy male adults, rice vs wheat diet crossover trial
399 fecal samples from healthy human male adults in a longitudinal crossover dietary intervention study comparing rice versus wheat staple consumption and its effects on the gut microbiome. machine-written summary
399 samples · 399 runs · CN · Adult · 2026 · 7.41 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,995 sample values (collection date, country, latitude, location region, longitude) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen design crossover · population healthy_control · Crossover rice vs wheat staple diet, strict dietary standardization
“longitudinal multi-omics crossover trial with 68 participants, utilizing strict dietary standardization” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 399 | 100% | ||||
| country | 399 | 100% | 399 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 399 | 100% | 399 | |||
| detailed_location | 399 | 100% | ||||
| latitude | 399 | 100% | 399 | |||
| location_region | 399 | 100% | 399 | |||
| longitude | 399 | 100% | 399 |
Archive description
Here, we conducted a longitudinal multi-omics crossover trial with 68 participants, utilizing strict dietary standardization to isolate the effects of rice versus wheat. We demonstrate that a single staple change is sufficient to restructure the gut microbiome, driving dynamic responses in specific bacterial taxa. Notably, habitual wheat consumers exhibited significantly higher glycemic variability after switching to rice, with Bifidobacterium longum serving as a pivotal modulator of this staple-dependent glycemic stability.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Fecal samples collected from”
- body site study.description · “to restructure the gut microbiome, driving dynamic”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “healthy human male adults for a dietary”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN53926950 | collection_date | 2020-12-07 | R1 | 0.90 | biosample.attribute:collection_date | 2020-12-07 |
| SAMN53926950 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Shanxi |
| SAMN53926950 | latitude | 36.1937 | R1 | 0.90 | biosample.attribute:lat_lon | 36.1937 N 113.1013 E |
| SAMN53926950 | location_region | Shanxi | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Shanxi |
| SAMN53926950 | longitude | 113.1013 | R1 | 0.90 | biosample.attribute:lat_lon | 36.1937 N 113.1013 E |
Sequencing
399 runs over 399 samples · mean 7.59 Gbp per run (median 7.41 Gbp, total 3,027.10 Gbp; 399 runs with a base count) · layout PAIRED 399 · platform ILLUMINA 399 · models Illumina NovaSeq 6000 (399) · 0% of runs with a Sandpiper profile · first public 2026-09-02
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA1380750.csv.gz (10.7 KB) · parquet (87.5 KB) — all 399 samples, every field with route and confidence · PRJNA1380750_determinations.csv.gz (14.7 KB) — 1,995 evidence rows