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PRJNA1390327 SRP656225

Gut microbiota in pregnancy loss vs healthy controls

Gut metagenome

Case-control metagenomic study of 212 adult gut samples comparing microbiota composition between individuals experiencing pregnancy loss and healthy controls. machine-written summary

212 samples · 212 runs · CN · Adult · 2025 · 25.21 Gbp / sample

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Sources
✓Sequence archive 1,407✓Abstract / description 142–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive1,407 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude)
✓ Abstract / description142 sample values (health condition detail)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet · share metadata
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
7 sampling locations · 1 country
Age
adult212
Condition
pregnancy_postpartum70
Country
CN212
Body site
primary212
Collected 2022–2023
2022: 47 samples2023: 165 samples20222023
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 5 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 178 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)this project, 30–100 Gbp: 29 samplesall projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 25.21 Gbp per sample0130Gbp
Community composition
Roseburia 13.5%Faecalibacterium 10.0%Phocaeicola 7.3%Gemmiger 5.8%Prevotella 4.9%Bacteroides 4.1%Megamonas 3.4%Ruminococcoides 2.7%Bifidobacterium 2.4%Lachnospira 2.4%Blautia_A 1.9%Dialister 1.9%not assigned to a genus 2.7%other genera 37.1%

Genera, mean relative abundance over 196 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category212 100%
country212 100%212
health_condition70 33%70
subject_id0 0%
collection_date212 100%212
detailed_location212 100%
health_condition_detail212 100%70142
latitude212 100%212
location_region212 100%212
longitude212 100%212
location_locality207 98%207
Details
Archive description

Investigate the microecological distribution and compositional differences in the gut microbiota of individuals experiencing pregnancy loss compared to healthy controls using metagenomic sequencing.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
  • body site study.title · “Gut metagenome”
  • body site study.description · “differences in the gut microbiota of individuals”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN54180936collection_date2023-03-06R10.90biosample.attribute:collection_date2023-03-06
SAMN54180936countryCNR10.90sample.attr.geo_loc_nameChina: No. 80, Cuiyingmen, Chengguan District, Lanzhou City, Gansu Province
SAMN54181080health_conditionpregnancy_postpartumR10.70sample.name_rule:library_namePL017
SAMN54181080health_condition_detailPLR10.70sample.name_rule:library_namePL017
SAMN54180936health_condition_detailmixed_case_control: pregnancy loss cases vs healthy controlsR40.50study.descriptionpregnancy loss compared to healthy
SAMN54180936latitude36.0672R10.90biosample.attribute:lat_lon36.067236 N 103.840521 E
SAMN54180936location_localityLanzhouR10.85biosample.attribute:geo_loc_nameChina: No. 80, Cuiyingmen, Chengguan District, Lanzhou City, Gansu Province
SAMN54180936location_regionGansuR10.85biosample.attribute:geo_loc_nameChina: No. 80, Cuiyingmen, Chengguan District, Lanzhou City, Gansu Province
SAMN54181070location_regionGansu ShengR10.60biosample.attribute:lat_lon40.286393 N 97.058527 E
SAMN54180936longitude103.8405R10.90biosample.attribute:lat_lon36.067236 N 103.840521 E
Sequencing

212 runs over 212 samples · mean 24.47 Gbp per run (median 25.21 Gbp, total 5,187.68 Gbp; 212 runs with a base count) · layout PAIRED 212 · platform ILLUMINA 212 · models Illumina NovaSeq 6000 (212) · 92% of runs with a Sandpiper profile · first public 2025-12-19

Authors (0)

No author record.

Help complete this project

2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata

Downloads

PRJNA1390327.csv.gz (6.5 KB) · parquet (79.1 KB) — all 212 samples, every field with route and confidence · PRJNA1390327_determinations.csv.gz (11.3 KB) — 1,549 evidence rows

Samples (212 · every field this project has values for · hover a cell for its source)
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