Gut microbiome in MCI vs healthy older adults, Tampa, USA
73 gut microbiome samples from older adults in Tampa, Florida, USA, comparing mild cognitive impairment (n=30) to cognitively healthy controls (n=43) in a case-control design examining gut permeability and inflammation. machine-written summary
73 samples · 73 runs · US · Adult · 2026 · 1.30 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 657 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 73 | 100% | ||||
| country | 73 | 100% | 73 | |||
| health_condition | 73 | 100% | 73 | |||
| subject_id | 73 | 100% | 73 | |||
| collection_date | 73 | 100% | 73 | |||
| detailed_location | 73 | 100% | ||||
| health_condition_detail | 73 | 100% | 73 | |||
| latitude | 73 | 100% | 73 | |||
| location_locality | 73 | 100% | 73 | |||
| location_region | 73 | 100% | 73 | |||
| longitude | 73 | 100% | 73 |
Archive description
Cognitive impairment and Alzheimer disease are increasing with population aging, yet early biological mechanisms remain unclear. Evidence suggests that gut dysbiosis and increased intestinal permeability, or leaky gut, promote systemic inflammation and cognitive decline. We analyzed clinical, inflammatory, and gut microbiome data from 73 older adults in the multi site Microbiome in Aging Gut and Brain (MiaGB) consortium to define links between leaky gut and mild cognitive impairment (MCI). Compared with cognitively healthy controls (n = 43), individuals with MCI (n = 30) showed higher gut permeability markers (LPS binding protein, CD14), increased LPS and toll like receptor 4 activation, and elevated inflammatory markers (IL-6, IL-1 beta, C-reactive protein). MCI was also associated with a distinct gut microbiota profile enriched in pathways related to the microbial metabolite 2 methylcitrate, which correlated with increased gut permeability and reduced cognitive function. These findings support a gut microbiota driven leaky gut inflammation axis contributing to early cognitive impairment and highlight potential biomarkers for early detection and intervention.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut Barrier Dysfunction, Inflammation,”
- body site study.description · “Evidence suggests that gut dysbiosis and increased”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “from 73 older adults in the multi”
- life stage study.description · “data from 73 older adults in the multi”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54187520 | collection_date | 2023-04-20 | R1 | 0.90 | biosample.attribute:collection_date | 2023-04-20 |
| SAMN54187520 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: Florida, Tampa |
| SAMN54187520 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:title | Human sample Control_1 |
| SAMN54187520 | health_condition_detail | Control | R1 | 0.70 | sample.name_rule:title | Human sample Control_1 |
| SAMN54187520 | latitude | 27.9517 | R1 | 0.90 | biosample.attribute:lat_lon | 27.9517 N 82.4588 W |
| SAMN54187520 | location_locality | Tampa | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Florida, Tampa |
| SAMN54187520 | location_region | Florida | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Florida, Tampa |
| SAMN54187520 | longitude | -82.4588 | R1 | 0.90 | biosample.attribute:lat_lon | 27.9517 N 82.4588 W |
| SAMN54187520 | subject_id | Control_1 | R1 | 0.70 | sample.name_rule:TITLE | Human sample Control_1 |
Sequencing
73 runs over 73 samples · mean 1.35 Gbp per run (median 1.30 Gbp, total 98.43 Gbp; 73 runs with a base count) · layout PAIRED 73 · platform ILLUMINA 73 · models NextSeq 1000 (73) · 0% of runs with a Sandpiper profile · first public 2026-08-05
Authors (0)
No author record.
Downloads
PRJNA1390647.csv.gz (2.8 KB) · parquet (73.6 KB) — all 73 samples, every field with route and confidence · PRJNA1390647_determinations.csv.gz (5.6 KB) — 657 evidence rows