Gut Metagenome in Chinese ALS Patients vs Healthy Controls
Case-control metagenome study of 22 adult samples from Chinese ALS patients and healthy controls, examining gut microbiota, virome, and metabolome dysbiosis in amyotrophic lateral sclerosis. machine-written summary
22 samples · 22 runs · CN · Adult · 2026 · 15.65 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 176 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 22 sample values (subject id) · PMC13227962 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 22 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 22 | 100% | ||||
| country | 22 | 100% | 22 | |||
| health_condition | 22 | 100% | 22 | |||
| subject_id | 22 | 100% | 22 | |||
| collection_date | 22 | 100% | 22 | |||
| detailed_location | 22 | 100% | ||||
| health_condition_detail | 22 | 100% | 22 | |||
| latitude | 22 | 100% | 22 | |||
| location_locality | 22 | 100% | 22 | |||
| location_region | 22 | 100% | 22 | |||
| longitude | 22 | 100% | 22 |
- Integrated multi-omics analysis reveals gut dysbiosis and altered energy metabolism in Chinese ALS patients. 2026 PMID 42059647 PMC13227962 own_data
Archive description
Metagenome of ALS and HC.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Metagenomics Reveals Gut Microbiota Dysbiosis in”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54375225 | collection_date | 2025-02-25 | R1 | 0.90 | biosample.attribute:collection_date | 2025-02-25 |
| SAMN54375225 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Hangzhou |
| SAMN54375225 | health_condition | neurological_psychiatric | R1 | 0.70 | sample.name_rule:library_names | ALS-1 |
| SAMN54375225 | health_condition_detail | ALS | R1 | 0.70 | sample.name_rule:library_names | ALS-1 |
| SAMN54375225 | latitude | 30.2741 | R1 | 0.90 | biosample.attribute:lat_lon | 30.2741 N 120.1551 E |
| SAMN54375225 | location_locality | Hangzhou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Hangzhou |
| SAMN54375225 | location_region | Zhejiang Sheng | R1 | 0.60 | biosample.attribute:lat_lon | 30.2741 N 120.1551 E |
| SAMN54375225 | longitude | 120.1551 | R1 | 0.90 | biosample.attribute:lat_lon | 30.2741 N 120.1551 E |
| SAMN54375225 | subject_id | SAMN54375225 | R3 | 0.75 | design.one_sample_per_subject:fulltext | Second, this is a cross-sectional study, preventing us from establishing causality; |
Sequencing
22 runs over 22 samples · mean 15.48 Gbp per run (median 15.65 Gbp, total 340.54 Gbp; 22 runs with a base count) · layout PAIRED 22 · platform ILLUMINA 22 · models Illumina NovaSeq X Plus (22) · 100% of runs with a Sandpiper profile · first public 2026-01-02
Downloads
PRJNA1395841.csv.gz (1.5 KB) · parquet (71.0 KB) — all 22 samples, every field with route and confidence · PRJNA1395841_determinations.csv.gz (2.2 KB) — 198 evidence rows