Bloodstream infection on antibiotics, gut microbiome
254 gut microbiome samples from adult patients receiving antibiotic treatment for bloodstream infection; no country or intervention details specified. machine-written summary
254 samples · 254 runs · CA · Adult · 2026 · 2.53 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 2,028 sample values (collection date, country, latitude, location locality, location region, longitude, subject id, timepoint) |
| ✓ Abstract / description | 254 sample values (antibiotic exposure) |
| ✓ Full text | 508 sample values (health condition, health condition detail) · PMC11935739 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure
longitudinal
76 of 124 people sampled more than once (204 samples; median 2, up to 4 per person) · follow-up median 13 d (max 21 d) · median interval between samples 7 d (time from timepoint labels). Schedule stated by the source: “rectal swabs at enrollment, day 7, and day 14” (time origin: enrolment); stated follow-up 14 d.
Each row is one person (36 shown of 76); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 182 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 254 | 100% | ||||
| country | 254 | 100% | 254 | |||
| health_condition | 254 | 100% | 254 | |||
| subject_id | 252 | 99% | 252 | |||
| antibiotic_exposure | 254 | 100% | 254 | |||
| collection_date | 254 | 100% | 254 | |||
| detailed_location | 254 | 100% | ||||
| health_condition_detail | 254 | 100% | 254 | |||
| latitude | 254 | 100% | 254 | |||
| location_locality | 254 | 100% | 254 | |||
| location_region | 254 | 100% | 254 | |||
| longitude | 254 | 100% | 254 | |||
| timepoint_label | 252 | 99% | 252 |
- Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial. 2025 PMID 40134637 PMC11935739 own_data
- Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial. 2026 PMID 42549478 own_data
Archive description
Gut microbiomes of patients receiving antibiotic treatment for bloodstream infection
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “BALANCE gut microbiome”
- body site study.description · “Gut microbiomes of patients”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54587600 | antibiotic_exposure | yes | R4 | 0.50 | paper.abstract | 7 or 14 days of antibiotics for treatment of bacteremia in a substudy |
| SAMN54587600 | collection_date | 2024 | R1 | 0.90 | biosample.attribute:collection_date | 2024 |
| SAMN54587600 | country | CA | R1 | 0.90 | sample.attr.geo_loc_name | Canada: Toronto |
| SAMN54587600 | health_condition | other_infection | R3 | 0.70 | paper.body.methods_results | Among the 3631 participants with bacteremia in the BALANCE RCT who were randomized |
| SAMN54587600 | health_condition_detail | bacteremia | R3 | 0.70 | paper.body.methods_results | Among the 3631 participants with bacteremia in the BALANCE RCT who were randomized |
| SAMN54587600 | latitude | 43.6548 | R1 | 0.90 | biosample.attribute:lat_lon | 43.6548 N 79.3884 W |
| SAMN54587600 | location_locality | Toronto | R1 | 0.85 | biosample.attribute:geo_loc_name | Canada: Toronto |
| SAMN54587600 | location_region | Ontario | R1 | 0.60 | biosample.attribute:lat_lon | 43.6548 N 79.3884 W |
| SAMN54587600 | longitude | -79.3884 | R1 | 0.90 | biosample.attribute:lat_lon | 43.6548 N 79.3884 W |
| SAMN54587601 | subject_id | 01-1051 | R1 | 0.70 | sample.name_rule:library_names | 01-1051-D14_S133 |
| SAMN54587601 | timepoint_label | D14 | R1 | 0.70 | sample.name_rule:library_names | 01-1051-D14_S133 |
Sequencing
254 runs over 254 samples · mean 2.55 Gbp per run (median 2.53 Gbp, total 647.21 Gbp; 254 runs with a base count) · layout PAIRED 254 · platform ILLUMINA 254 · models Illumina NovaSeq X (254) · 73% of runs with a Sandpiper profile · first public 2026-01-20
Authors (0)
No author record.
Downloads
PRJNA1402308.csv.gz (7.4 KB) · parquet (80.2 KB) — all 254 samples, every field with route and confidence · PRJNA1402308_determinations.csv.gz (20.7 KB) — 2,790 evidence rows