Adolescent obesity gut microbiome case-control study (POMMS)
396 stool samples from adolescents aged 10-18 with severe obesity and healthy-weight controls, profiled for gut microbiome features alongside serum metabolomics, in a case-control design with a 6-month obesity intervention. machine-written summary
396 samples · 396 runs · Child · 2026 · 6.74 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ○ Sequence archive | records read; no usable sample values |
| ✓ Abstract / description | 383 sample values (health condition detail) |
| ✓ Full text | 792 sample values (location region, location site) · PMC13367979 |
| ✓ Supplementary tables | 65 sample values (health condition, health condition detail, sex, subject id, timepoint) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Other administered intervention (see intervention_detail) · population obesity · 6-month obesity weight loss intervention; FMT into germ-free mice from human donors
“Fecal microbiome transplants (FMT) were performed on germ-free mice” — abstract:42454489 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “Baseline and 6-month timepoints for OB group (shotgun); HWC sampled at baseline only” (time origin: enrolment); stated follow-up 6 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 396 | 100% | ||||
| country | 0 | 0% | ||||
| health_condition | 13 | 3% | 13 | |||
| subject_id | 13 | 3% | 13 | |||
| detailed_location | 396 | 100% | ||||
| health_condition_detail | 396 | 100% | 13 | 383 | ||
| location_region | 396 | 100% | 396 | |||
| location_site | 396 | 100% | 396 | |||
| sex | 13 | 3% | 13 | |||
| timepoint_label | 13 | 3% | 13 |
- Branched chain amino acid metabolism and microbiome in adolescents with obesity during weight loss therapy. 2026 PMID 42454489 PMC13367979 own_data
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- body site external_curation.infant_catalog · “body_site_call stool”
- life stage external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54636483 | health_condition | healthy_control | R2 | 0.85 | paper.supp.jci-136-196742-s115.xlsx[Fig 5A!Group] | HWC |
| SAMN54636483 | health_condition_detail | HWC | R2 | 0.85 | paper.supp.jci-136-196742-s115.xlsx[Fig 5A!Group] | HWC |
| SAMN54636460 | health_condition_detail | mixed_case_control: adolescents with severe obesity vs healthy weight controls | R4 | 0.40 | paper.abstract | 220 adolescents aged 10-18 with severe obesity (OB) and 67 individuals who |
| SAMN54636460 | location_region | North Carolina | R3 | 0.60 | paper.fulltext.results | Durham, North Carolina, USA |
| SAMN54636460 | location_site | Duke Healthy Lifestyles Clinic | R3 | 0.60 | paper.fulltext.results | referral to the Duke Healthy Lifestyles Clinic in Durham |
| SAMN54636483 | sex | female | R2 | 0.85 | paper.supp.jci-136-196742-s115.xlsx[Fig 5A!Sex] | F |
| SAMN54636483 | subject_id | DU125 | R2 | 0.85 | paper.supp.jci-136-196742-s115.xlsx[Fig 5A!PID] | DU125 |
| SAMN54636483 | timepoint_label | R24 Baseline | R2 | 0.85 | paper.supp.jci-136-196742-s115.xlsx[Fig 5A!Timepoint] | R24 Baseline |
Sequencing
396 runs over 396 samples · mean 6.84 Gbp per run (median 6.74 Gbp, total 2,707.07 Gbp; 396 runs with a base count) · layout PAIRED 396 · platform ILLUMINA 396 · models Illumina NovaSeq 6000 (396) · 0% of runs with a Sandpiper profile · first public 2026-05-24
Authors (24)
McCann JR first · Yang C · Bihlmeyer NA · Tang R · Truong T · Zhou W · An J · Jawahar J · Ilkayeva O · Muehlbauer MJ · Hu Z · Dressman HK · Poppe L · Granek JA · Arnold JW · David LA · Oh J · Shi P · Gumus Balikcioglu P · Shah SH · Armstrong SC · Newgard CB · Seed PC · Rawls JF last
Help complete this project
3 of the 4 core fields are below 50% coverage: country, health_condition, subject_id. Share metadata
Downloads
PRJNA1403442.csv.gz (9.6 KB) · parquet (84.6 KB) — all 396 samples, every field with route and confidence · PRJNA1403442_determinations.csv.gz (7.1 KB) — 1,240 evidence rows