Gut microbiome and brain health in US Veterans with mTBI
Cross-sectional study of 92 samples from US Veterans with history of mild traumatic brain injury, examining gut microbiome diversity, taxonomy, and metabolic pathways in relation to LIBRA brain health scores. machine-written summary
92 samples · 92 runs · US · Adult · 2026 · 8.40 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 644 sample values (age, bmi, collection date, country, latitude, location region, longitude) |
| ✓ Abstract / description | 184 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 91 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 92 | 100% | ||||
| country | 92 | 100% | 92 | |||
| health_condition | 92 | 100% | 92 | |||
| subject_id | 0 | 0% | ||||
| age_at_collection_days | 92 | 100% | 92 | |||
| bmi | 92 | 100% | 92 | |||
| collection_date | 92 | 100% | 92 | |||
| detailed_location | 92 | 100% | ||||
| health_condition_detail | 92 | 100% | 92 | |||
| latitude | 92 | 100% | 92 | |||
| location_region | 92 | 100% | 92 | |||
| longitude | 92 | 100% | 92 |
Archive description
Mild traumatic brain injuries (mTBIs) are highly prevalent among United States Veterans, particularly those with a history of deployments. mTBIs can cause inflammation, a necessary component of healing. Persistent inflammation however, may disrupt overall health and alter the gut microbiome, the diverse community of microorganisms in the digestive tract. The bidirectional relationship between the brain and gut, known as the gut-brain axis, has garnered increasing attention due to its role in neuroinflammation and recovery. The complex relationship between the gut-brain axis, multiple biological mechanisms, and health outcomes encourages the use of broad health measures to fully capture the role of the gut microbiome in mTBI. The goal of this study was to assess The LIfestyle for BRAin (LIBRA) scores, a measure of brain health, and their relationship with gut microbiome diversity, taxonomic abundance, and metabolic pathways.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Microbiome- Gut -Brain Axis Biomarkers”
- body site study.description · “and alter the gut microbiome, the diverse”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.host_age · “65 (n=17/92)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54721707 | age_at_collection_days | 11312.8 | R1 | 0.85 | sample.attr.host_age | 31 |
| SAMN54721707 | bmi | 29.75 | R1 | 0.90 | sample.attr.host_body_mass_index | 29.75 |
| SAMN54721707 | collection_date | 2022 | R1 | 0.90 | biosample.attribute:collection_date | 2022 |
| SAMN54721707 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA |
| SAMN54721707 | health_condition | neurological_psychiatric | R4 | 0.45 | study.title | History of Traumatic Brain Injury |
| SAMN54721707 | health_condition_detail | mild traumatic brain injury (mTBI) history | R4 | 0.45 | study.title | History of Traumatic Brain Injury |
| SAMN54721707 | latitude | 39.7422 | R1 | 0.90 | biosample.attribute:lat_lon | 39.742248 N 104.829860 W |
| SAMN54721707 | location_region | Colorado | R1 | 0.60 | biosample.attribute:lat_lon | 39.742248 N 104.829860 W |
| SAMN54721707 | longitude | -104.8299 | R1 | 0.90 | biosample.attribute:lat_lon | 39.742248 N 104.829860 W |
Sequencing
92 runs over 92 samples · mean 8.46 Gbp per run (median 8.40 Gbp, total 778.23 Gbp; 92 runs with a base count) · layout PAIRED 92 · platform ILLUMINA 92 · models Illumina NovaSeq 6000 (92) · 99% of runs with a Sandpiper profile · first public 2026-01-24
Authors (0)
No author record.
Downloads
PRJNA1404669.csv.gz (3.9 KB) · parquet (75.1 KB) — all 92 samples, every field with route and confidence · PRJNA1404669_determinations.csv.gz (7.2 KB) — 828 evidence rows