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PRJNA1405914 SRP665065

Gut microbiota in heart failure vs healthy controls

Gut microbiota-derived 5-hydroxyindoleacetic acid drives macrophage-dependent cardiac remodeling through the AHR-NFATC2-ITGA4 axis

23 gut microbiome samples from adults (mostly) and one elderly individual, comparing patients with heart failure to healthy controls in a case-control design; no location or intervention specified. machine-written summary

23 samples · 23 runs · CN · Adult · 2026 · 0.13 Gbp / sample

Sources
✓Sequence archive 161–Abstract / description–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive161 sample values (age, collection date, country, health condition, health condition detail, sex, subject id)
– Abstract / descriptionno abstract or project description
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
adult22
elderly1
Condition
healthy_control12
cardiometabolic_other11
Sex
male12
female11
Country
CN23
Body site
primary23
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)this project, 0.03–0.1 Gbp: 4 samplesall projects, 0.1–0.3 Gbp: 29,179 samples (5 %)this project, 0.1–0.3 Gbp: 19 samplesall projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)all projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 0.13 Gbp per sample0130Gbp
Community composition
Bacteroides 12.3%Alistipes 5.3%Parabacteroides 5.2%Phocaeicola 4.3%Roseburia 4.2%Faecalibacterium 4.1%Lachnospira 2.9%Mediterraneibacter 2.8%Parasutterella 2.3%Bilophila 2.3%Enterocloster 1.9%Blautia_A 1.9%not assigned to a genus 7.4%other genera 43.2%

Genera, mean relative abundance over 19 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category23 100%
country23 100%23
health_condition23 100%23
subject_id23 100%23
age_at_collection_days23 100%23
collection_date23 100%23
health_condition_detail23 100%23
sex23 100%23
Details
Archive description

Detect the differences in the gut microbiota between healthy controls and patients with heart failure

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
  • body site study.title · “Gut microbiota-derived 5-hydroxyindoleacetic acid”
  • body site study.description · “differences in the gut microbiota between healthy”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN54757364age_at_collection_days16436.2R10.70sample.attr.age45
SAMN54757364collection_date2023-07R10.90biosample.attribute:collection_date2023-07
SAMN54757364countryCNR10.90sample.attr.geo_loc_nameChina
SAMN54757364health_conditionhealthy_controlR10.70sample.name_rule:library_nameHealthy1
SAMN54757364health_condition_detailHealthy1R10.70sample.name_rule:library_nameHealthy1
SAMN54757364sexmaleR10.90sample.attr.sexmale
SAMN54757364subject_idSUBJ001_FECESR10.85biosample.attribute:isolateSUBJ001_FECES
Sequencing

23 runs over 23 samples · mean 0.14 Gbp per run (median 0.13 Gbp, total 3.25 Gbp; 23 runs with a base count) · layout SINGLE 23 · platform ILLUMINA 23 · models Illumina HiSeq 2000 (23) · 83% of runs with a Sandpiper profile · first public 2026-01-23 – 2026-01-24

Authors (0)

No author record.

Downloads

PRJNA1405914.csv.gz (1.7 KB) · parquet (70.9 KB) — all 23 samples, every field with route and confidence · PRJNA1405914_determinations.csv.gz (2.2 KB) — 161 evidence rows

Samples (23 · every field this project has values for · hover a cell for its source)
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