Gut Microbiome in Neonatal Lupus, China (Case-Control)
90 gut metagenome samples from neonates in China (Suzhou, Xi'an, Huaian, Yangzhou), comparing healthy controls, anti-Ro-antibody-positive neonates without NLE, and neonates with neonatal lupus erythematosus, in a case-control design. machine-written summary
90 samples · 90 runs · CN · Infant / toddler · 2026 · 8.52 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 570 sample values (age, collection date, country, health condition, health condition detail, sex, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 90 sample values (antibiotic exposure) · PMC13596901 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 90 | 100% | ||||
| country | 90 | 100% | 90 | |||
| health_condition | 60 | 67% | 60 | |||
| subject_id | 90 | 100% | 90 | |||
| age_at_collection_days | 90 | 100% | 90 | |||
| antibiotic_exposure | 90 | 100% | 90 | |||
| collection_date | 90 | 100% | 90 | |||
| sex | 90 | 100% | 90 | |||
| health_condition_detail | 60 | 67% | 60 |
- Gut microbiota functional remodeling and butyrate depletion amplify anti-Ro/La antibody-driven type I interferon activation in neonatal lupus. 2026 PMID 42747315 PMC13596901 own_data
Archive description
This dataset includes metagenomic sequencing data from neonates to investigate gut microbiome alterations in the context of immune modulation. The data represents three distinct groups: healthy controls, neonates with anti-Ro antibodies but without neonatal lupus erythematosus (NLE), and neonates diagnosed with NLE. This resource aims to provide insights into the potential role of gut microbiome dysbiosis in the development of autoimmune conditions during early life and its influence on immune system development.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and neonate by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “Gut Microbiome Dysbiosis in”
- body site study.description · “neonates to investigate gut microbiome alterations in”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “autoimmune conditions during early life and its influence”
- life stage study.title · “Microbiome Dysbiosis in Neonatal Lupus”
- life stage study.description · “sequencing data from neonates to investigate gut”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54894984 | age_at_collection_days | 8 | R1 | 0.90 | biosample_attr | 8 days |
| SAMN54894984 | antibiotic_exposure | no | R3 | 0.70 | paper.body.methods_results | None of the neonates had received antibiotics or probiotic supplementation before sample collection. |
| SAMN54894984 | collection_date | 2024 | R1 | 0.85 | biosample.attribute:collection_date | 2024 |
| SAMN54894984 | country | CN | R1 | 0.90 | biosample_attr | China: Suzhou |
| SAMN54894984 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:sample_alias | Ctrl1 |
| SAMN54894984 | health_condition_detail | Ctrl | R1 | 0.70 | sample.name_rule:sample_alias | Ctrl1 |
| SAMN54894984 | sex | female | R1 | 0.90 | biosample_attr | female |
| SAMN54894984 | subject_id | Ctrl1 | R1 | 0.50 | biosample_attr | Ctrl1 |
Sequencing
90 runs over 90 samples · mean 9.09 Gbp per run (median 8.52 Gbp, total 818.32 Gbp; 90 runs with a base count) · layout PAIRED 90 · platform DNBSEQ 90 · models DNBSEQ-T7 (90) · 0% of runs with a Sandpiper profile · first public 2026-08-13
Authors (0)
No author record.
Downloads
PRJNA1414141.csv.gz (3.5 KB) · parquet (74.5 KB) — all 90 samples, every field with route and confidence · PRJNA1414141_determinations.csv.gz (5.4 KB) — 660 evidence rows