Tacrolimus and gut microbiota, liver transplant, China
36 fecal samples from liver transplant patients in Kunming, China, treated with tacrolimus, analyzed by shotgun metagenomics and LC-MS/MS metabolomics in a cross-sectional design stratified by treatment duration and drug concentration. machine-written summary
36 samples · 36 runs · CN · Adult · 2026 · 10.18 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 216 sample values (age, collection date, country, location locality, sex, subject id) |
| ✓ Abstract / description | 72 sample values (health condition, health condition detail) |
| ✓ Full text | 36 sample values (location site) · PMC12944773 |
| ✓ Supplementary tables | 143 sample values (antibiotic exposure, bmi, medication, timepoint) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 36 | 100% | ||||
| country | 36 | 100% | 36 | |||
| health_condition | 36 | 100% | 36 | |||
| subject_id | 36 | 100% | 36 | |||
| age_at_collection_days | 36 | 100% | 36 | |||
| antibiotic_exposure | 36 | 100% | 36 | |||
| bmi | 36 | 100% | 36 | |||
| collection_date | 36 | 100% | 36 | |||
| detailed_location | 36 | 100% | ||||
| health_condition_detail | 36 | 100% | 36 | |||
| location_locality | 36 | 100% | 36 | |||
| location_site | 36 | 100% | 36 | |||
| sex | 36 | 100% | 36 | |||
| timepoint_label | 36 | 100% | 36 | |||
| medication | 35 | 97% | 35 |
- Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients. 2026 PMID 41746975 PMC12944773 own_data
Archive description
The aim of this study is to investigate the impact of tacrolimus on the gut microbiota of LT patients. Patients were grouped based on the duration of tacrolimus use, whole blood drug concentration, and concentration-dose ratio. The Illumina HiSeq X platform was employed to detect the gut metagenome, analyzing the composition and characteristics of the gut microbiota. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology was used to measure gut microbiota metabolites and reveal their metabolic profiles.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by opus_adjudicated with confidence 0.80. Assay shotgun_dna.
- host study.description · “gut microbiota of LT patients”
- host run.scientific_name · “Homo sapiens”
- body site study.description · “detect the gut metagenome”
- life stage sample.attr.age · “54 (n=26/36)”
- life stage sample.attr.age · “66 (n=7/36)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN54971508 | age_at_collection_days | 18614.0 | R1 | 0.85 | sample.attr.age | 51 |
| SAMN54971508 | antibiotic_exposure | yes | R2 | 0.80 | paper.supp.pone.0343817.s001.xlsx[Sheet1!Antibacterial Drugs] | Yes |
| SAMN54971508 | bmi | 20.42 | R2 | 0.80 | paper.supp.pone.0343817.s001.xlsx[Sheet1!BMI (kg/m²)] | 20.4152249134948 |
| SAMN54971508 | collection_date | 2024-01-29 | R1 | 0.90 | biosample.attribute:collection_date | 2024-01-29 |
| SAMN54971508 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Kunming |
| SAMN54971508 | health_condition | transplant_or_immunocompromised | R4 | 0.50 | paper.abstract | patients who received tacrolimus treatment after liver transplantation |
| SAMN54971508 | health_condition_detail | liver transplant recipients on tacrolimus immunosuppression | R4 | 0.50 | paper.abstract | patients who received tacrolimus treatment after liver transplantation |
| SAMN54971508 | location_locality | Kunming | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Kunming |
| SAMN54971508 | location_site | First People's Hospital of Kunming City | R3 | 0.70 | paper.fulltext.methods | First People's Hospital of Kunming City |
| SAMN54971508 | medication | immunosuppressant_or_biologic | R2 | 0.80 | paper.supp.pone.0343817.s001.xlsx[Sheet1!Immunosuppressive Drugs] | Mycophenolate Mofetil |
| SAMN54971508 | sex | male | R1 | 0.90 | sample.attr.sex | male |
| SAMN54971508 | subject_id | patient1 | R1 | 0.70 | sample.name_rule:isolate | patient1 |
| SAMN54971508 | timepoint_label | >3 months | R2 | 0.80 | paper.supp.pone.0343817.s001.xlsx[Sheet1!Transplant Time Stage] | >3 months |
Sequencing
36 runs over 36 samples · mean 10.36 Gbp per run (median 10.18 Gbp, total 372.85 Gbp; 36 runs with a base count) · layout PAIRED 36 · platform DNBSEQ 36 · models DNBSEQ-T7 (36) · 0% of runs with a Sandpiper profile · first public 2026-02-10
Downloads
PRJNA1416570.csv.gz (2.5 KB) · parquet (73.7 KB) — all 36 samples, every field with route and confidence · PRJNA1416570_determinations.csv.gz (5.0 KB) — 467 evidence rows