Neonatal jaundice gut metagenome, randomized probiotic trial
383 gut metagenome samples from infants with jaundice, studying a probiotic intervention using a randomized trial design. machine-written summary
383 samples · 383 runs · CN · Infant / toddler · 2026 · 6.57 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,875 sample values (collection date, country, intervention, subject id, timepoint) |
| ✓ Abstract / description | 383 sample values (health condition) |
| ✓ Full text | 1,532 sample values (antibiotic exposure, location site, maternal antibiotics, preterm status) · PMC13079629 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population other_disease · Bifidobacterium M-16V and/or Bb-12 probiotics vs phototherapy-only control, 4 arms
“Phototherapy Control, M-16V, Bb-12, and the combined M-16V+Bb-12 group” — abstract:41994268 (study level; per-sample arms are in the intervention column below)
longitudinal
84 of 90 people sampled more than once (366 samples; median 4, up to 8 per person) · follow-up median 3 mo (max 5 mo) · median interval between samples 16 d (time from collection dates).
Each row is one person (36 shown of 84); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 383 | 100% | ||||
| country | 383 | 100% | 383 | |||
| health_condition | 383 | 100% | 383 | |||
| subject_id | 372 | 97% | 372 | |||
| antibiotic_exposure | 383 | 100% | 383 | |||
| collection_date | 383 | 100% | 383 | |||
| detailed_location | 383 | 100% | ||||
| location_site | 383 | 100% | 383 | |||
| maternal_antibiotics | 383 | 100% | 383 | |||
| preterm_status | 383 | 100% | 383 | |||
| timepoint_label | 371 | 97% | 371 | |||
| intervention | 366 | 96% | 366 |
- The enhancing therapeutic effect of neonatal jaundice by <i>bifidobacterium</i> through regulating inflammation and gut microbiota in combination with phototherapy-a randomized controlled trial. PMID 41994268 PMC13079629 curated
Archive description
Macrogene sequencing technology was used to sequence and analyze the collected neonatal feces with jaundice.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and neonate by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “Gut metagenome”
- body site study.description · “the collected neonatal feces with jaundice.”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “analyze the collected neonatal feces with jaundice.”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN55572888 | antibiotic_exposure | no | R3 | 0.60 | paper.fulltext.methods | No prior use of antibiotics or ecological agents before specimen collection |
| SAMN55572888 | collection_date | 2020-09-01 | R1 | 0.85 | biosample.attribute:collection_date | 2020-09-01 |
| SAMN55572888 | country | CN | R1 | 0.90 | biosample_attr | China:Shanghai |
| SAMN55572888 | health_condition | other_disease | R4 | 0.50 | paper.abstract | 79 jaundiced neonates were enrolled |
| SAMN55572888 | intervention | no_intervention | R1 | 0.70 | sample.name_rule:library_names | 120C0D2 |
| SAMN55572888 | location_site | NICU of Lingang Campus, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University | R3 | 0.70 | paper.fulltext.methods | neonates hospitalized in the NICU of the Lingang Campus |
| SAMN55572888 | maternal_antibiotics | no | R3 | 0.60 | paper.fulltext.methods | no intake of antibiotics or microecological agents before, during, or after childbirth |
| SAMN55572888 | preterm_status | term | R3 | 0.60 | paper.fulltext.methods | Term infants with gestational age ≥37 weeks and <42 weeks |
| SAMN55572888 | subject_id | 120 | R1 | 0.70 | sample.name_rule:library_names | 120C0D2 |
| SAMN55892740 | subject_id | 062 | R1 | 0.70 | sample.name_rule:library_name | 062T2D0 |
| SAMN55572888 | timepoint_label | D2 | R1 | 0.70 | sample.name_rule:library_names | 120C0D2 |
| SAMN56289074 | timepoint_label | E | R1 | 0.70 | sample.name_rule:library_name | T2P001E_FDSW210413234 |
Sequencing
383 runs over 383 samples · mean 6.61 Gbp per run (median 6.57 Gbp, total 2,531.73 Gbp; 383 runs with a base count) · layout PAIRED 383 · platform ILLUMINA 383 · models Illumina NovaSeq 6000 (383) · 0% of runs with a Sandpiper profile · first public 2026-04-19
Authors (13)
Zhang F first · Chen J · Yuan Y · Jiang W · Xiang W · Wang N · Wu Z · Fan S · Zhang K · Ma Y · Liu T · Zhang J · Yu Q
Downloads
PRJNA1425751.csv.gz (13.8 KB) · parquet (88.7 KB) — all 383 samples, every field with route and confidence · PRJNA1425751_determinations.csv.gz (30.7 KB) — 3,790 evidence rows