Gut microbiome in older adults given probiotic KM2-HPB01
198 fecal samples from adults aged 50 and older in a randomized, placebo-controlled trial testing the probiotic intervention KM2-HPB01, analyzed by shotgun metagenomic sequencing to assess gut microbial composition and function. machine-written summary
198 samples · 198 runs · KR · Adult · 2026 · 4.40 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 990 sample values (collection date, country, intervention, subject id, timepoint) |
| ✓ Abstract / description | 396 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population healthy_control · KM2-HPB01 probiotic vs placebo in adults 50+
“randomized, placebo-controlled clinical trial investigating the effects of KM2-HPB01” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
66 of 66 people sampled more than once (198 samples; median 3, up to 3 per person) · follow-up median 3 mo (max 3 mo) · median interval between samples 42 d (time from collection dates). Schedule stated by the source: “Each subject sampled at week 0 (baseline), week 6, and week 12 of the trial” (time origin: intervention start (trial enrollment/baseline, week 0)); stated follow-up 3 mo.
Each row is one person (36 shown of 66); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 198 | 100% | ||||
| country | 198 | 100% | 198 | |||
| health_condition | 198 | 100% | 198 | |||
| subject_id | 198 | 100% | 198 | |||
| collection_date | 198 | 100% | 198 | |||
| health_condition_detail | 198 | 100% | 198 | |||
| intervention | 198 | 100% | 198 | |||
| timepoint_label | 198 | 100% | 198 |
Archive description
This BioProject contains shotgun metagenomic sequencing data generated from human fecal samples collected from adults aged 50 years and older enrolled in a randomized, placebo-controlled clinical trial investigating the effects of KM2-HPB01 administration on gut microbiome composition. Paired-end Illumina sequencing was performed to characterize microbial community structure and functional potential.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “sequencing of human fecal samples from adults”
- body site study.description · “generated from human fecal samples collected from”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “fecal samples from adults aged 50 years”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN61422580 | collection_date | 2023-10-12 | R1 | 0.90 | biosample.attribute:collection_date | 2023-10-12 |
| SAMN61422580 | country | KR | R1 | 0.90 | sample.attr.geo_loc_name | South Korea |
| SAMN61422580 | health_condition | healthy_control | R4 | 0.50 | study.title | randomized placebo-controlled trial of KM2-HPB01 |
| SAMN61422580 | health_condition_detail | intervention trial with KM2-HPB01 vs placebo | R4 | 0.50 | study.title | randomized placebo-controlled trial of KM2-HPB01 |
| SAMN61422580 | intervention | other_intervention | R1 | 0.70 | sample.name_rule:sample_alias | KM2_T001_W0 |
| SAMN61422580 | subject_id | T001 | R1 | 0.70 | sample.name_rule:sample_alias | KM2_T001_W0 |
| SAMN61422580 | timepoint_label | week 0 | R1 | 0.70 | sample.name_rule:sample_alias | KM2_T001_W0 |
Sequencing
198 runs over 198 samples · mean 4.49 Gbp per run (median 4.40 Gbp, total 888.28 Gbp; 198 runs with a base count) · layout PAIRED 198 · platform ILLUMINA 198 · models NextSeq 2000 (198) · 0% of runs with a Sandpiper profile · first public 2026-09-01
Authors (0)
No author record.
Downloads
PRJNA1430192.csv.gz (6.3 KB) · parquet (77.8 KB) — all 198 samples, every field with route and confidence · PRJNA1430192_determinations.csv.gz (10.7 KB) — 1,386 evidence rows