Gut microbiome in RA-ILD vs RA vs healthy controls
41 fecal samples from rheumatoid arthritis patients with interstitial lung disease, RA patients without ILD, and healthy controls, analyzed by shotgun metagenomic sequencing in a case-control design. machine-written summary
41 samples · 41 runs · CN · Adult · 2026 · 13.34 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 246 sample values (collection date, country, health condition, health condition detail, location locality, location region) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 82 sample values (antibiotic exposure, subject id) · PMC13303103 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 41 | 100% | ||||
| country | 41 | 100% | 41 | |||
| health_condition | 41 | 100% | 41 | |||
| subject_id | 41 | 100% | 41 | |||
| antibiotic_exposure | 41 | 100% | 41 | |||
| collection_date | 41 | 100% | 41 | |||
| detailed_location | 41 | 100% | ||||
| health_condition_detail | 41 | 100% | 41 | |||
| location_locality | 41 | 100% | 41 | |||
| location_region | 41 | 100% | 41 |
- Metagenomic characterization of gut microbiota in rheumatoid arthritis-associated interstitial lung disease: taxonomic shifts and clinical correlations. 2026 PMID 42367778 PMC13303103 own_data
Archive description
This study investigates the gut microbiome structure and function in patients with rheumatoid arthritis complicated by interstitial lung disease. Metagenomic sequencing data will be analyzed to understand the relationship between gut microbiota and disease progression.
How this project entered the registry
Classified as human gut / stool / lower respiratory shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbiome structure and”
- body site study.description · “study investigates the gut microbiome structure and”
- body site study.title · “complicated by interstitial lung disease”
- body site study.description · “complicated by interstitial lung disease. Metagenomic sequencing”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN56641257 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | antibiotic, probiotic, or prebiotic use within 3 months |
| SAMN56641257 | collection_date | 2023 | R1 | 0.90 | biosample.attribute:collection_date | 2023 |
| SAMN56641257 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Suqian, Jiangsu |
| SAMN56641257 | health_condition | healthy_control | R1 | 0.90 | biosample_attr | healthy |
| SAMN56641257 | health_condition_detail | healthy | R1 | 0.90 | sample.attr.host_disease | healthy |
| SAMN56641257 | location_locality | Suqian | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Suqian, Jiangsu |
| SAMN56641257 | location_region | Jiangsu | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Suqian, Jiangsu |
| SAMN56641257 | subject_id | SAMN56641257 | R3 | 0.75 | design.one_sample_per_subject:fulltext | This cross-sectional observational study was conducted at the Department of Rheumatology and Immunology, Suqian First Hospital |
Sequencing
41 runs over 41 samples · mean 13.98 Gbp per run (median 13.34 Gbp, total 573.14 Gbp; 41 runs with a base count) · layout PAIRED 41 · platform ILLUMINA 41 · models Illumina NovaSeq 6000 (41) · 0% of runs with a Sandpiper profile · first public 2026-04-02
Downloads
PRJNA1441104.csv.gz (2.0 KB) · parquet (71.5 KB) — all 41 samples, every field with route and confidence · PRJNA1441104_determinations.csv.gz (2.8 KB) — 328 evidence rows