Microbiota transplant therapy in children with Pitt-Hopkins
62 gut microbiome samples from children with Pitt-Hopkins syndrome (a rare neurodevelopmental disorder), studying antibiotic, bowel preparation, and fecal microbiota transplant intervention in a randomized, placebo-controlled trial. machine-written summary
62 samples · 62 runs · US · Child · 2026 · 3.13 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 621 sample values (antibiotic exposure, collection date, country, health condition, intervention, intervention detail, latitude, location region) |
| ✓ Abstract / description | 65 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
6 people have samples in more than one arm.
Antibiotic given as the study intervention (incl. eradication therapy Bowel cleansing / colonoscopy preparation Faecal microbiota transplantation design randomized_controlled_trial · population neurological_psychiatric · Microbiota transplant therapy with antibiotics and bowel cleansing pretreatment, RCT vs placebo
“combination of antibiotics, bowel cleansing, and transplant of healthy donor microbiota” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
6 of 26 people sampled more than once (42 samples; median 7, up to 8 per person).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 62 | 100% | ||||
| country | 62 | 100% | 62 | |||
| health_condition | 62 | 100% | 59 | 3 | ||
| subject_id | 62 | 100% | 62 | |||
| collection_date | 62 | 100% | 62 | |||
| detailed_location | 62 | 100% | ||||
| health_condition_detail | 62 | 100% | 62 | |||
| intervention | 62 | 100% | 62 | |||
| intervention_detail | 62 | 100% | 62 | |||
| latitude | 62 | 100% | 62 | |||
| location_region | 62 | 100% | 62 | |||
| longitude | 62 | 100% | 62 | |||
| timepoint_label | 60 | 97% | 60 | |||
| antibiotic_exposure | 6 | 10% | 6 |
- Microbiota Transplant Therapy (MTT) Improves Gastrointestinal Symptoms in Children with Pitt-Hopkins Syndrome: A Randomized Clinical Trial 2026 own_data
Archive description
This study investigates Microbiota Transplant Therapy (MTT) as a treatment for children with Pitt-Hopkins Syndrome who suffer from gastrointestinal (GI) problems. It uses a combination of antibiotics, bowel cleansing, and transplant of healthy donor microbiota to restore gut balance. The trial is designed as a randomized, placebo-controlled study to assess safety, tolerability, and effectiveness. Results suggest that MTT can improve GI symptoms by reshaping the gut microbiome. The research also explores how changes in gut bacteria may influence broader neurological and behavioral symptoms in this rare disorder.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- body site study.title · “Therapy (MTT) Improves Gastrointestinal Symptoms by Modulating”
- body site study.description · “who suffer from gastrointestinal (GI) problems. It”
- life stage external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- life stage study.title · “Gut Microbiota in Children with Pitt-Hopkins Syndrome,”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN56787990 | antibiotic_exposure | yes | R1 | 0.85 | biosample.attribute:Group_for_case_control | Group_for_case_control: Vanco |
| SAMN56787986 | collection_date | 2024 | R1 | 0.90 | biosample.attribute:collection_date | 2024 |
| SAMN56787986 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA:Ariozna |
| SAMN56787986 | health_condition | neurological_psychiatric | R1 | 0.85 | biosample_attr | Placebo |
| SAMN56787988 | health_condition | neurological_psychiatric | R4 | 0.50 | study.title | Pitt-Hopkins Syndrome, A Rare Neurodevelopmental Disorder |
| SAMN56787986 | health_condition_detail | Pitt-Hopkins Syndrome, a rare neurodevelopmental disorder with GI problems. | R4 | 0.50 | study.title | Pitt-Hopkins Syndrome, A Rare Neurodevelopmental Disorder |
| SAMN56787986 | intervention | no_intervention | R1 | 0.90 | biosample.attribute:Group_for_case_control | Group_for_case_control: Baseline |
| SAMN56787987 | intervention | antibiotic | R1 | 0.80 | biosample.attribute:ReGroup | ReGroup: Vanco |
| SAMN56787986 | intervention_detail | Pre-intervention baseline | R1 | 0.90 | biosample.attribute:Group_for_case_control | Group_for_case_control: Baseline |
| SAMN56787987 | intervention_detail | Vancomycin antibiotic | R1 | 0.80 | biosample.attribute:ReGroup | ReGroup: Vanco |
| SAMN56787986 | latitude | 33.4194 | R1 | 0.90 | biosample.attribute:lat_lon | 33.4194 N 111.9281 W |
| SAMN56787986 | location_region | Arizona | R1 | 0.60 | biosample.attribute:lat_lon | 33.4194 N 111.9281 W |
| SAMN56787986 | longitude | -111.9281 | R1 | 0.90 | biosample.attribute:lat_lon | 33.4194 N 111.9281 W |
| SAMN56787986 | subject_id | PH002 | R1 | 0.85 | sample.attr.patient_id | PH002 |
| SAMN56787986 | timepoint_label | Baseline | R1 | 0.85 | biosample.attribute:Group_for_case_control | Group_for_case_control: Baseline |
Sequencing
62 runs over 62 samples · mean 3.21 Gbp per run (median 3.13 Gbp, total 198.82 Gbp; 62 runs with a base count) · layout PAIRED 62 · platform ILLUMINA 62 · models Illumina NovaSeq 6000 (62) · 0% of runs with a Sandpiper profile · first public 2026-04-05
Authors (0)
No author record.
Downloads
PRJNA1445352.csv.gz (2.9 KB) · parquet (73.6 KB) — all 62 samples, every field with route and confidence · PRJNA1445352_determinations.csv.gz (6.1 KB) — 686 evidence rows