Oral cancer vs healthy controls, gut microbiome
25 gut metagenome samples from a hospital-based case-control study comparing oral cancer patients and matched healthy controls, used to validate Mendelian randomization findings on gut microbiota and circulating metabolites in oral cancer. machine-written summary
25 samples · 25 runs · CN · Adult · 2026 · 7.00 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 200 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC13233540 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 25 | 100% | ||||
| country | 25 | 100% | 25 | |||
| health_condition | 25 | 100% | 25 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 25 | 100% | 25 | |||
| detailed_location | 25 | 100% | ||||
| health_condition_detail | 25 | 100% | 25 | |||
| latitude | 25 | 100% | 25 | |||
| location_locality | 25 | 100% | 25 | |||
| location_region | 25 | 100% | 25 | |||
| longitude | 25 | 100% | 25 |
- Insights into the effects of gut microbiota and circulating metabolites on oral cancer: Mendelian randomization analysis and clinical validation. 2026 PMID 42253727 PMC13233540 own_data
Archive description
We recruited a total of 12 patients diagnosed with oral cancer and 12 matched healthy controls who had not received any treatment before sampling. All participants were recruited from our hospital between July and October 2025. To ensure comparability between groups, we maintained consistency in all factors other than oral cancer, including gender, age, lifestyle, and dietary habits. Healthy controls were recruited from the physical examination center of our hospital.
How this project entered the registry
Classified as human oral cavity / gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “circulating metabolites on oral cancer”
- body site study.description · “patients diagnosed with oral cancer and 12”
- body site study.title · “the effects of gut microbiota and circulating”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN58176786 | collection_date | 2025-08-10 | R1 | 0.90 | biosample.attribute:collection_date | 2025-08-10 |
| SAMN58176786 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Chongqing |
| SAMN58176786 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:isolation_source | Human fecal sample from a healthy adult |
| SAMN58176786 | health_condition_detail | Human fecal sample from a healthy adult | R1 | 0.85 | biosample.attribute:isolation_source | Human fecal sample from a healthy adult |
| SAMN58176786 | latitude | 29.5600 | R1 | 0.90 | biosample.attribute:lat_lon | 29.56 N 106.56 E |
| SAMN58176786 | location_locality | Chongqing | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Chongqing |
| SAMN58176786 | location_region | Chongqing Shi | R1 | 0.60 | biosample.attribute:lat_lon | 29.56 N 106.56 E |
| SAMN58176786 | longitude | 106.5600 | R1 | 0.90 | biosample.attribute:lat_lon | 29.56 N 106.56 E |
Sequencing
25 runs over 25 samples · mean 7.27 Gbp per run (median 7.00 Gbp, total 181.86 Gbp; 25 runs with a base count) · layout PAIRED 25 · platform ILLUMINA 25 · models Illumina NovaSeq 6000 (25) · 0% of runs with a Sandpiper profile · first public 2026-05-06
Downloads
PRJNA1461404.csv.gz (1.6 KB) · parquet (71.1 KB) — all 25 samples, every field with route and confidence · PRJNA1461404_determinations.csv.gz (2.0 KB) — 200 evidence rows