WGS stool metagenomics, drug therapy case-control, Russia
218 stool metagenome samples from hospitalized patients and controls across Arkhangelsk and Moscow, Russia, collected before and after hospital therapy to study drug therapy effects on gut microbiome in a case-control design. machine-written summary
218 samples · 218 runs · RU · Age unknown · 2026 · 6.05 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,744 sample values (collection date, country, latitude, location locality, location region, longitude, subject id, timepoint) |
| ✓ Abstract / description | 218 sample values (health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design observational_with_procedure · Hospital therapy medications; stool sampled before admission and after discharge
“impact of different therapy medications on gut microbiome” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
109 of 109 people sampled more than once (218 samples; median 2, up to 2 per person) · follow-up median 7 d (max 19 d) · median interval between samples 7 d (time from collection dates). Schedule stated by the source: “Stool collected before hospital admission and after discharge (median hospitalization 6 days)” (time origin: admission); stated follow-up 6 d.
Each row is one person (36 shown of 109); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 218 | 100% | 218 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 218 | 100% | 218 | |||
| collection_date | 218 | 100% | 218 | |||
| detailed_location | 218 | 100% | ||||
| health_condition_detail | 218 | 100% | 218 | |||
| latitude | 218 | 100% | 218 | |||
| location_locality | 218 | 100% | 218 | |||
| location_region | 218 | 100% | 218 | |||
| longitude | 218 | 100% | 218 | |||
| timepoint_label | 218 | 100% | 218 |
Archive description
This project stores WGS metagenomics data of stool samples of 109 patients and control group participants from 3 hospitals of Central Region of Russia to study the impact of different therapy medications on gut microbiome composition. Faecal metagenomic samples were collected at two timepoints (before admission and after hospital discharge (median time of hospitalization 6 days)), sequenced and analyzed by ARGs and taxonomic composition.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human feces metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN60357914 | collection_date | 2024-05-21 | R1 | 0.90 | biosample.attribute:collection_date | 2024-05-21 |
| SAMN60357914 | country | RU | R1 | 0.90 | sample.attr.geo_loc_name | Russia: Arkhangelsk |
| SAMN60357914 | health_condition_detail | mixed_case_control: Study includes both patients (disease status unspecified) and control group participants; no single | R4 | 0.50 | study.description | patients and control group participants |
| SAMN60357914 | latitude | 64.5425 | R1 | 0.90 | biosample.attribute:lat_lon | 64.542465 N 40.537319 E |
| SAMN60357914 | location_locality | Arkhangelsk | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Arkhangelsk |
| SAMN60357914 | location_region | Arkhangelskaya | R1 | 0.60 | biosample.attribute:lat_lon | 64.542465 N 40.537319 E |
| SAMN60358058 | location_region | Moscow | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Moscow |
| SAMN60357914 | longitude | 40.5373 | R1 | 0.90 | biosample.attribute:lat_lon | 64.542465 N 40.537319 E |
| SAMN60357914 | subject_id | B-001 | R1 | 0.70 | sample.name_rule:library_names | B-001-1 |
| SAMN60357914 | timepoint_label | before admission | R1 | 0.70 | sample.name_rule:library_names | B-001-1 |
Sequencing
218 runs over 218 samples · mean 6.41 Gbp per run (median 6.05 Gbp, total 1,397.35 Gbp; 218 runs with a base count) · layout PAIRED 218 · platform DNBSEQ 218 · models DNBSEQ-G400 (218) · 0% of runs with a Sandpiper profile · first public 2026-06-21
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1469445.csv.gz (7.3 KB) · parquet (80.3 KB) — all 218 samples, every field with route and confidence · PRJNA1469445_determinations.csv.gz (15.3 KB) — 1,962 evidence rows