Gut metagenome, melanoma on immunotherapy, 2 timepoints
32 fecal samples from melanoma patients (24 adult, 8 elderly), collected before and 3 months after starting immune checkpoint inhibitor therapy, in a longitudinal design. machine-written summary
32 samples · 64 runs · RU · Adult · 2026 · 4.44 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 320 sample values (age, collection date, country, latitude, location locality, location region, longitude, sex) |
| ✓ Abstract / description | 64 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Non-antibiotic pharmaceutical given as the study intervention (metformin · population other_cancer · Immune checkpoint inhibitor immunotherapy, pre- vs 3-month post-treatment
“response to immune checkpoint inhibitor (ICI) immunotherapy” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
16 of 16 people sampled more than once (32 samples; median 2, up to 2 per person). Schedule stated by the source: “prior to treatment initiation and 3 month after treatment onset” (time origin: treatment_start); stated follow-up 3 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 32 | 100% | ||||
| country | 32 | 100% | 32 | |||
| health_condition | 32 | 100% | 32 | |||
| subject_id | 32 | 100% | 32 | |||
| age_at_collection_days | 32 | 100% | 32 | |||
| collection_date | 32 | 100% | 32 | |||
| detailed_location | 32 | 100% | ||||
| health_condition_detail | 32 | 100% | 32 | |||
| latitude | 32 | 100% | 32 | |||
| location_locality | 32 | 100% | 32 | |||
| location_region | 32 | 100% | 32 | |||
| longitude | 32 | 100% | 32 | |||
| sex | 32 | 100% | 32 | |||
| timepoint_label | 32 | 100% | 32 |
Archive description
For a longitudinal study of gut microbiome dynamics in response to immune checkpoint inhibitor (ICI) immunotherapy, fecal samples were collected from 16 melanoma patients at two timepoints: prior to treatment initiation and 3 month after treatment onset.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Human gut metagenome from melanoma”
- body site study.description · “longitudinal study of gut microbiome dynamics in”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.age · “62 (n=14/32)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN60358217 | age_at_collection_days | 29220.0 | R1 | 0.70 | sample.attr.age | 80 |
| SAMN60358217 | collection_date | 2025 | R1 | 0.90 | biosample.attribute:collection_date | 2025 |
| SAMN60358217 | country | RU | R1 | 0.90 | sample.attr.geo_loc_name | Russia: Moscow |
| SAMN60358217 | health_condition | other_cancer | R4 | 0.50 | study.description | 16 melanoma patients |
| SAMN60358217 | health_condition_detail | melanoma | R4 | 0.50 | study.description | melanoma patients |
| SAMN60358217 | latitude | 55.4500 | R1 | 0.90 | biosample.attribute:lat_lon | 55.45 N 37.37 E |
| SAMN60358217 | location_locality | Moscow | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Moscow |
| SAMN60358217 | location_region | Moscow | R1 | 0.85 | biosample.attribute:geo_loc_name | Russia: Moscow |
| SAMN60358217 | longitude | 37.3700 | R1 | 0.90 | biosample.attribute:lat_lon | 55.45 N 37.37 E |
| SAMN60358217 | sex | male | R1 | 0.90 | sample.attr.sex | male |
| SAMN60358217 | subject_id | Long_1 | R1 | 0.70 | sample.name_rule:alias | Long_1_1 |
| SAMN60358217 | timepoint_label | 1 | R1 | 0.85 | sample.attr.time_point | 1 |
Sequencing
64 runs over 32 samples · mean 2.30 Gbp per run (median 3.02 Gbp, total 147.45 Gbp; 64 runs with a base count) · layout PAIRED 32, SINGLE 32 · platform ILLUMINA 32, OXFORD_NANOPORE 32 · models NextSeq 1000 (32), PromethION (32) · 0% of runs with a Sandpiper profile · first public 2026-09-01
Authors (0)
No author record.
Downloads
PRJNA1469454.csv.gz (1.8 KB) · parquet (71.7 KB) — all 32 samples, every field with route and confidence · PRJNA1469454_determinations.csv.gz (3.1 KB) — 384 evidence rows