Gut microbiome in arsenic-exposed rural Bolivians
Cross-sectional shotgun metagenomics of 130 gut microbiome samples from a rural Bolivian population exposed to arsenic, examining microbial genes correlated with urinary arsenic levels. machine-written summary
130 samples · 130 runs · BO · Age unknown · 2026 · 7.23 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 520 sample values (collection date, country, latitude, longitude) |
| ✓ Abstract / description | 520 sample values (health condition, health condition detail, lifestyle, lifestyle detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 130 | 100% | 130 | |||
| health_condition | 130 | 100% | 130 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 130 | 100% | 130 | |||
| health_condition_detail | 130 | 100% | 130 | |||
| latitude | 130 | 100% | 130 | |||
| lifestyle | 130 | 100% | 130 | |||
| lifestyle_detail | 130 | 100% | 130 | |||
| longitude | 130 | 100% | 130 |
Archive description
Using gene-level and species-level shotgun metagenomics, we provide the first characterization of the rural, Bolivian microbiome we identified microbial genes which strongly correlate (rho>0.45) with arsenic in urine, and that overall contribute to substantiate that the gut microbiome helps tolerate arsenic via a evict-out-of-house mechanism. Mediation analysis, followed by phylogenetic investigation of metagenomic-assembled genomes, further strengthens this observation. This study elucidates the role of the microbiome in helping to tolerate arsenic-rich environments, and paves the way for probiotic interventions that may mitigate the effects of this toxic metal.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.62. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN60498414 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMN60498414 | country | BO | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Bolivia |
| SAMN60498414 | health_condition | other_disease | R4 | 0.30 | study.title | Bolivian Arsenic-exposed populations |
| SAMN60498414 | health_condition_detail | arsenic-exposed populations | R4 | 0.50 | study.title | Arsenic-exposed populations |
| SAMN60498414 | latitude | -19.0366 | R1 | 0.90 | biosample.attribute:latitude_and_longitude | 19.0366 S 68.0889 W |
| SAMN60498414 | lifestyle | rural_non_industrialized | R4 | 0.45 | ena.study_description | rural, Bolivian microbiome |
| SAMN60498414 | lifestyle_detail | rural Bolivian population exposed to arsenic | R4 | 0.45 | ena.study_description | rural, Bolivian microbiome |
| SAMN60498414 | longitude | -68.0889 | R1 | 0.90 | biosample.attribute:latitude_and_longitude | 19.0366 S 68.0889 W |
Sequencing
130 runs over 130 samples · mean 7.95 Gbp per run (median 7.23 Gbp, total 1,032.98 Gbp; 130 runs with a base count) · layout PAIRED 130 · platform ILLUMINA 130 · models Illumina NovaSeq 6000 (130) · 0% of runs with a Sandpiper profile · first public 2026-05-31
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata
Downloads
PRJNA1472498.csv.gz (4.1 KB) · parquet (75.1 KB) — all 130 samples, every field with route and confidence · PRJNA1472498_determinations.csv.gz (5.6 KB) — 1,040 evidence rows