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PRJNA1472528 SRP704954

Fecal Metagenomes in Crohn's Disease on Pea Protein ONS

Fecal Microbiome Profiling in Crohns Disease During Oral Nutritional Supplementation

66 fecal metagenome samples from adults with Crohn's disease, collected longitudinally during an intervention comparing pea protein based oral nutritional supplementation versus placebo. machine-written summary

66 samples · 66 runs · US · Adult · 2026 · 6.06 Gbp / sample

Sources
✓Sequence archive 594–Abstract / description–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive594 sample values (country, health condition, health condition detail, intervention, latitude, location region, longitude, subject id)
– Abstract / descriptionno abstract or project description
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Interventions

intervention · arms resolved

RNon-microbial dietary supplement (vitamins: 10 people · 36 samplessupplement 10 people · 36 samplesPlacebo / sham arm (sample level only): 10 people · 30 samplesplacebo 10 people · 30 samples
randomised to parallel arms

Non-microbial dietary supplement (vitamins design randomized_controlled_trial · population crohns_disease · Pea protein oral nutritional supplementation vs placebo

“pea protein based oral nutritional supplementation or placebo” — bioproject.description (study level; per-sample arms are in the intervention column below)

Samples at a glance
1 sampling locations · 1 country
Age
adult66
Condition
crohns_disease66
Country
US66
Body site
primary66
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)this project, 0.03–0.1 Gbp: 1 samplesall projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 1 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 11 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 52 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 1 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 6.06 Gbp per sample0130Gbp
Sampling design and relatedness

longitudinal

18 of 20 people sampled more than once (64 samples; median 4, up to 5 per person) · follow-up median 42 d (max 42 d) · median interval between samples 21 d (time from timepoint labels).

K022K022: day 0K022: day 14K022: day 420 d10 d21 d32 d42 d

Each row is one person (1 shown of 18); dots are samples at days since that person's first sample.

How longitudinal and relatedness information is derived

Community composition

No Sandpiper profile for this project's samples yet.

Field coverage
fieldsamplescoverageR1R2R3R4
age_category66 100%
country66 100%66
health_condition66 100%66
subject_id66 100%66
detailed_location66 100%
health_condition_detail66 100%66
intervention66 100%66
latitude66 100%66
location_region66 100%66
longitude66 100%66
timepoint_label66 100%66
Details
Archive description

Longitudinal metagenomic sequence reads of fecal samples in Crohns disease patients receiving pea protein based oral nutritional supplementation or placebo.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.68. Assay shotgun_dna.

  • host study.description · “Crohns disease patients receiving pea protein”
  • body site study.title · “Fecal Microbiome Profiling”
  • life stage study.title · “Crohns Disease”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN60503344countryUSR10.90sample.attr.geo_loc_nameUSA:Minnesota
SAMN60503344health_conditioncrohns_diseaseR10.70sample.name_rule:titleBL sample from participant K001 in ONS group
SAMN60503344health_condition_detailparticipantR10.70sample.name_rule:titleBL sample from participant K001 in ONS group
SAMN60503344interventiondietary_supplementR10.70sample.name_rule:titleBL sample from participant K001 in ONS group
SAMN60503344latitude44.9723R10.90biosample.attribute:lat_lon44.9723 N 93.2335 W
SAMN60503344location_regionMinnesotaR10.85biosample.attribute:geo_loc_nameUSA:Minnesota
SAMN60503344longitude-93.2335R10.90biosample.attribute:lat_lon44.9723 N 93.2335 W
SAMN60503344subject_idK001R10.70sample.name_rule:titleBL sample from participant K001 in ONS group
SAMN60503344timepoint_labelBLR10.70sample.name_rule:titleBL sample from participant K001 in ONS group
Sequencing

66 runs over 66 samples · mean 5.91 Gbp per run (median 6.06 Gbp, total 389.81 Gbp; 66 runs with a base count) · layout PAIRED 66 · platform ELEMENT 66 · models Element AVITI (66) · 0% of runs with a Sandpiper profile · first public 2026-06-19

Authors (0)

No author record.

Downloads

PRJNA1472528.csv.gz (2.6 KB) · parquet (72.9 KB) — all 66 samples, every field with route and confidence · PRJNA1472528_determinations.csv.gz (5.7 KB) — 594 evidence rows

Samples (66 · every field this project has values for · hover a cell for its source)
Loading the sample table…