Gut microbiome in aging adults with MCI, Washington DC
39 longitudinal gut metagenome samples from older adults (50-90y) around Washington, DC, comparing healthy controls and mild cognitive impairment, integrated with cognitive, dietary, and behavioral assessments. machine-written summary
39 samples · 39 runs · US · Mixed ages · 2026 · 0.16 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 415 sample values (antibiotic exposure, bmi, collection date, country, diet, diet detail, health condition, health condition detail) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 39 sample values (location locality) · PMC13251516 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal
12 of 16 people sampled more than once (35 samples; median 3, up to 4 per person) · follow-up median 6 mo (max 10 mo) · median interval between samples 3 mo (time from collection dates). Schedule stated by the source: “Participants sampled at baseline, 3 months, and 6 months with repeated stool collection and cognitive/behavioral assessments at each visit.” (time origin: enrolment).
Each row is one person (11 shown of 12); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 39 | 100% | ||||
| country | 39 | 100% | 39 | |||
| health_condition | 39 | 100% | 39 | |||
| subject_id | 39 | 100% | 39 | |||
| bmi | 39 | 100% | 39 | |||
| collection_date | 39 | 100% | 39 | |||
| detailed_location | 39 | 100% | ||||
| health_condition_detail | 39 | 100% | 39 | |||
| location_locality | 39 | 100% | 39 | |||
| sex | 39 | 100% | 39 | |||
| diet | 37 | 95% | 37 | |||
| diet_detail | 37 | 95% | 37 | |||
| medication | 29 | 74% | 29 | |||
| medication_detail | 29 | 74% | 29 | |||
| lifestyle | 4 | 10% | 4 | |||
| lifestyle_detail | 4 | 10% | 4 | |||
| antibiotic_exposure | 2 | 5% | 2 |
- Brain health and the gut microbiome (bMicrobiome Study): a proof-of-concept, feasibility study integrating shotgun metagenomics, metrology, and multidimensional phenotyping across the cognitive aging spectrum. 2026 PMID 42282268 PMC13251516 own_data
Archive description
This prospective, proof-of-concept study integrated multidimensional phenotyping with metagenomic sequencing (shotgun) in adults (50-90 years) around Washington, DC. Participants were classified as healthy controls (HC) or mild cognitive impairment (MCI) by clinical history early Alzheimer's disease (eAD) participants were unable to complete study requirements. Longitudinal assessment used Boston Cognitive Assessment (BoCA), patient-reported outcomes (PROMIS-29), dietary intake and quality (DietID), readiness-for-change (adapted URICA), at-home stool sample collection.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
- life stage study.description · “adults (50-90 years)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN60643533 | antibiotic_exposure | yes | R1 | 0.85 | biosample_attr | Levothyroxine sodium 100 mcg daily; Bupropion HCL ER (LX) 150 mcg daily; Diclofenac sodium 75 mg twice daily; Tylenol ex |
| SAMN60643521 | bmi | 22.0 | R1 | 0.90 | sample.attr.host_body_mass_index | 22 |
| SAMN60643521 | collection_date | 2024-01-15 | R1 | 0.90 | biosample.attribute:collection_date | 2024-01-15 |
| SAMN60643521 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA |
| SAMN60643521 | diet | other_diet | R1 | 0.90 | biosample.attribute:host_diet | Flexitarian |
| SAMN60643521 | diet_detail | Flexitarian | R1 | 0.90 | biosample.attribute:host_diet | Flexitarian |
| SAMN60643521 | health_condition | healthy_control | R1 | 0.90 | biosample_attr | healthy |
| SAMN60643521 | health_condition_detail | none reported | R1 | 0.90 | sample.attr.liver_disord | none reported |
| SAMN60643535 | lifestyle | vegetarian_or_vegan | R1 | 0.85 | biosample.attribute:host_diet | Vegetarian |
| SAMN60643535 | lifestyle_detail | Vegetarian | R1 | 0.85 | biosample.attribute:host_diet | Vegetarian |
| SAMN60643521 | location_locality | Washington, DC metropolitan area | R3 | 0.70 | paper.fulltext.methods | adults aged 50-90 y residing in the Washington, DC metropolitan area |
| SAMN60643523 | medication | antihypertensive;other_medication;statin | R1 | 0.85 | biosample.attribute:ihmc_medication_code | Lisinopril 40 mg daily, Hydrochlorothiazide 25 mg daily, Pravastatin 40 mg, Levothyroxine |
| SAMN60643523 | medication_detail | Lisinopril 40 mg daily, Hydrochlorothiazide 25 mg daily, Pravastatin 40 mg, Levothyroxine 25 mcg daily, Vitamin D 4000 UI daily, Vitamin C 500 mg daily, Areds f | R1 | 0.85 | biosample.attribute:ihmc_medication_code | Lisinopril 40 mg daily, Hydrochlorothiazide 25 mg daily, Pravastatin 40 mg, Levothyroxine |
| SAMN60643521 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMN60643521 | subject_id | BM1-028 | R1 | 0.85 | sample.attr.host_subject_id | BM1-028 |
Sequencing
39 runs over 39 samples · mean 0.16 Gbp per run (median 0.16 Gbp, total 6.07 Gbp; 39 runs with a base count) · layout PAIRED 39 · platform ELEMENT 39 · models Element AVITI (39) · 0% of runs with a Sandpiper profile · first public 2026-06-09
Authors (24)
Frame LA first · Warren A · Al Qalam A · Corr PG · Farah M · Karam M · Rangoussis K · Fahim Devin M · Celikkol Z · Gordon L · Villarreal D · Catto E · Udam Y · Thompson K · Lubinski O · Samman A · Badawi A · Hack H · Hunter M · Hines I · Servetas S · Jackson SA · Hasan NA · Kogan M last
Downloads
PRJNA1475489.csv.gz (3.7 KB) · parquet (76.4 KB) — all 39 samples, every field with route and confidence · PRJNA1475489_determinations.csv.gz (9.8 KB) — 454 evidence rows