Gut microbiome in type 2 diabetes vs healthy controls
82 fecal samples in a case-control study comparing adults with type 2 diabetes mellitus (41 samples) to age-, sex-, and BMI-matched healthy controls (41 samples); no location specified. machine-written summary
82 samples · 82 runs · CN · Adult · 2026 · 7.51 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 656 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude, sex) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 82 sample values (subject id) · PMC13522148 |
| ✓ Supplementary tables | 246 sample values (age, antibiotic exposure, bmi) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 82 | 100% | ||||
| country | 82 | 100% | 82 | |||
| health_condition | 82 | 100% | 82 | |||
| subject_id | 82 | 100% | 82 | |||
| age_at_collection_days | 82 | 100% | 82 | |||
| antibiotic_exposure | 82 | 100% | 82 | |||
| bmi | 82 | 100% | 82 | |||
| collection_date | 82 | 100% | 82 | |||
| detailed_location | 82 | 100% | ||||
| health_condition_detail | 82 | 100% | 82 | |||
| latitude | 82 | 100% | 82 | |||
| location_region | 82 | 100% | 82 | |||
| longitude | 82 | 100% | 82 | |||
| sex | 82 | 100% | 82 |
- Multi-layer gut microbiome variation in type 2 diabetes despite preserved higher-order community structure. 2026 PMID 42666298 PMC13522148 own_data
Archive description
Type 2 diabetes mellitus (T2DM) is a major metabolic disorder associated with alterations in the gut microbiome. This project generated whole-metagenome shotgun sequencing data from fecal samples collected from individuals with T2DM and healthy controls. The study aims to characterize taxonomic and functional changes in the gut microbiome and to identify microbial signatures associated with T2DM. The resulting dataset provides a resource for investigating host-microbiome interactions, microbial biomarkers, and microbiome-related mechanisms involved in metabolic diseases.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “profiling of the gut microbiome in type”
- body site study.description · “alterations in the gut microbiome. This project”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN60650026 | age_at_collection_days | 15340 | R2 | 0.85 | paper.supp.Table_1.xlsx[Clinical and demographic charac!Age] | 42 |
| SAMN60650026 | antibiotic_exposure | no | R2 | 0.85 | paper.supp.Table_1.xlsx[Clinical and demographic charac!Antibiotic_exposure] | No |
| SAMN60650026 | bmi | 29.74 | R2 | 0.85 | paper.supp.Table_1.xlsx[Clinical and demographic charac!BMI] | 29.7370443382672 |
| SAMN60650026 | collection_date | 2025-12-06/2025-12-19 | R1 | 0.90 | biosample.attribute:collection_date | 2025-12-06/2025-12-19 |
| SAMN60650026 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Henan |
| SAMN60650026 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:description | Control_fecal_metagenome |
| SAMN60650026 | health_condition_detail | Control_fecal_metagenome | R1 | 0.85 | biosample.attribute:description | Control_fecal_metagenome |
| SAMN60650026 | latitude | 34.4332 | R1 | 0.90 | biosample.attribute:lat_lon | 34.4332 N 115.6597 E |
| SAMN60650026 | location_region | Henan | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Henan |
| SAMN60650026 | longitude | 115.6597 | R1 | 0.90 | biosample.attribute:lat_lon | 34.4332 N 115.6597 E |
| SAMN60650026 | sex | male | R1 | 0.85 | biosample.attribute:title | Male_fecal_metagenome_sample |
| SAMN60650026 | subject_id | SAMN60650026 | R3 | 0.75 | design.one_sample_per_subject:fulltext | the cross-sectional design precludes inference of temporal relationships and causality |
Sequencing
82 runs over 82 samples · mean 8.33 Gbp per run (median 7.51 Gbp, total 683.36 Gbp; 82 runs with a base count) · layout PAIRED 82 · platform DNBSEQ 82 · models DNBSEQ-T7 (82) · 0% of runs with a Sandpiper profile · first public 2026-08-08
Downloads
PRJNA1475610.csv.gz (3.5 KB) · parquet (75.5 KB) — all 82 samples, every field with route and confidence · PRJNA1475610_determinations.csv.gz (8.6 KB) — 984 evidence rows