Microbiota & methotrexate response in rheumatic arthritis
312 samples from treatment-naive patients with rheumatoid arthritis and spondyloarthritis in Germany, comparing gut microbial signatures associated with methotrexate response in a case-control design. machine-written summary
312 samples · 312 runs · DE · Age unknown · 2026 · 7.42 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 2,007 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ✓ Abstract / description | 267 sample values (health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 312 | 100% | 312 | |||
| health_condition | 45 | 14% | 45 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 312 | 100% | 312 | |||
| detailed_location | 312 | 100% | ||||
| health_condition_detail | 312 | 100% | 45 | 267 | ||
| latitude | 312 | 100% | 312 | |||
| location_locality | 312 | 100% | 312 | |||
| location_region | 312 | 100% | 312 | |||
| longitude | 312 | 100% | 312 | |||
| timepoint_label | 45 | 14% | 45 |
Archive description
The human gut microbiota is increasingly recognized as a key factor influencing inflammatory diseases and treatment outcomes. However, whether microbial signatures are unique or shared across the stability of disease-specific microbial signatures across closely related rheumatic conditions remains unclear. In this study, we compared the gut microbiome of treatment-naive patients diagnosed with rheumatoid arthritis and spondyloarthritis.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.80. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.title · “Gut Microbiota Signatures”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN61283671 | collection_date | 2021-06-15 | R1 | 0.90 | biosample.attribute:collection_date | 2021-06-15 |
| SAMN61283671 | country | DE | R1 | 0.90 | sample.attr.geo_loc_name | Germany: Braunschweig |
| SAMN61283938 | health_condition | autoimmune_inflammatory | R1 | 0.70 | sample.name_rule:alias | 20230713_RV_MR_072_F2_5717a_152_RA_4_S168 |
| SAMN61283938 | health_condition_detail | RA | R1 | 0.70 | sample.name_rule:alias | 20230713_RV_MR_072_F2_5717a_152_RA_4_S168 |
| SAMN61283671 | health_condition_detail | mixed_case_control: treatment-naive rheumatoid arthritis and spondyloarthritis patients | R4 | 0.50 | study.description | treatment-naive patients diagnosed with rheumatoid arthritis and spondyloarthritis |
| SAMN61283671 | latitude | 52.2112 | R1 | 0.90 | biosample.attribute:lat_lon | 52.2112 N 10.5310 E |
| SAMN61283671 | location_locality | Braunschweig | R1 | 0.85 | biosample.attribute:geo_loc_name | Germany: Braunschweig |
| SAMN61283671 | location_region | Lower Saxony | R1 | 0.60 | biosample.attribute:lat_lon | 52.2112 N 10.5310 E |
| SAMN61283671 | longitude | 10.5310 | R1 | 0.90 | biosample.attribute:lat_lon | 52.2112 N 10.5310 E |
| SAMN61283938 | timepoint_label | F2 | R1 | 0.70 | sample.name_rule:source_material_id | 072_F2_5717a |
Sequencing
312 runs over 312 samples · mean 8.08 Gbp per run (median 7.42 Gbp, total 2,521.90 Gbp; 312 runs with a base count) · layout PAIRED 312 · platform ILLUMINA 312 · models Illumina NovaSeq 6000 (312) · 0% of runs with a Sandpiper profile · first public 2026-07-05
Authors (0)
No author record.
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJNA1477909.csv.gz (9.2 KB) · parquet (83.4 KB) — all 312 samples, every field with route and confidence · PRJNA1477909_determinations.csv.gz (17.5 KB) — 2,274 evidence rows