Gut microbiota, bile acids, and acute GvHD after HCT
245 stool samples from a longitudinal case-control study of allogeneic hematopoietic cell transplant recipients with and without acute gut graft-versus-host disease, examining gut microbiome and bile acid metabolism. machine-written summary
245 samples · 245 runs · US · Age unknown · 2026 · 8.13 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,225 sample values (country, location locality, location region, subject id, timepoint) |
| ✓ Abstract / description | 245 sample values (health condition detail) |
| ✓ Full text | 490 sample values (collection date, location site) · PMC13391574 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
83 of 98 people sampled more than once (230 samples; median 3, up to 3 per person). Schedule stated by the source: “Stool collected at three time points: pre-transplant, day 30 post-transplant, day 60 post-transplant (±7 days)” (time origin: transplant); stated follow-up 2 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 245 | 100% | 245 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 245 | 100% | 245 | |||
| collection_date | 245 | 100% | 245 | |||
| detailed_location | 245 | 100% | ||||
| health_condition_detail | 245 | 100% | 245 | |||
| location_locality | 245 | 100% | 245 | |||
| location_region | 245 | 100% | 245 | |||
| location_site | 245 | 100% | 245 | |||
| timepoint_label | 245 | 100% | 245 |
- Acute gastrointestinal graft-versus-host disease is associated with reductions of secondary bile acids following allogeneic hematopoietic cell transplantation. 2026 PMID 42495148 PMC13391574 own_data
Archive description
The Project examines the role of bile acids and the gut microbiota in graft versus host disease
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.68. Assay shotgun_dna.
- host study.description · “gut microbiota in graft versus host disease”
- body site study.title · “Gut microbiota and graft versus host disease”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN60991134 | collection_date | 2013-04/2020-03 | R3 | 0.70 | paper.fulltext.methods | between April 2013 and March 2020 |
| SAMN60991134 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: Seattle, WA |
| SAMN60991134 | health_condition_detail | mixed_case_control: acute gastrointestinal graft-versus-host disease patients vs controls without GvHD | R4 | 0.50 | paper.abstract | patients with and without acute gut GvHD |
| SAMN60991134 | location_locality | Seattle | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Seattle, WA |
| SAMN60991134 | location_region | Washington | R1 | 0.75 | biosample.attribute:geo_loc_name | USA: Seattle, WA |
| SAMN60991134 | location_site | Fred Hutchinson Cancer Center | R3 | 0.70 | paper.fulltext.methods | allogeneic HCT at the Fred Hutchinson Cancer Center in Seattle, WA |
| SAMN60991134 | subject_id | 001 | R1 | 0.70 | sample.name_rule:unique_sample_name | wgs_part_001_01 |
| SAMN60991134 | timepoint_label | 01 | R1 | 0.70 | sample.name_rule:unique_sample_name | wgs_part_001_01 |
Sequencing
245 runs over 245 samples · mean 9.54 Gbp per run (median 8.13 Gbp, total 2,337.17 Gbp; 245 runs with a base count) · layout PAIRED 245 · platform ILLUMINA 245 · models Illumina NovaSeq 6000 (245) · 0% of runs with a Sandpiper profile · first public 2026-06-19 – 2026-06-20
Authors (15)
Cagle R first · Proll S · Minot SS · Purcell H · Zhu W · Djukovic D · Liu C · Fiedler T · DeMeules M · Mielcarek M · Srinivasan S · Raftery D · Wu M · Pergam SA · Fredricks DN last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA1479378.csv.gz (7.2 KB) · parquet (79.5 KB) — all 245 samples, every field with route and confidence · PRJNA1479378_determinations.csv.gz (13.8 KB) — 1,960 evidence rows