Gut microbiota in cirrhosis, portal hypertension, lactulose
143 fecal samples from adult and elderly patients with cirrhosis and portal hypertension, collected at baseline and 4 weeks after starting lactulose therapy, in an intervention study. machine-written summary
143 samples · 143 runs · US · Adult · 2026 · 0.77 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,287 sample values (age, collection date, country, health condition, health condition detail, location region, sex, subject id) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design single_arm_before_after · population liver_disease · Lactulose given to cirrhosis patients, sampled at baseline and 4 weeks
“prior to initiating lactulose” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
30 of 30 people sampled more than once (143 samples; median 2, up to 15 per person). Schedule stated by the source: “Fecal samples and ANT collected at baseline (prior to lactulose) and at 4 weeks after starting lactulose” (time origin: intervention start (initiating lactulose)); stated follow-up 28 d.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 143 | 100% | ||||
| country | 143 | 100% | 143 | |||
| health_condition | 143 | 100% | 143 | |||
| subject_id | 143 | 100% | 143 | |||
| age_at_collection_days | 143 | 100% | 143 | |||
| collection_date | 143 | 100% | 143 | |||
| detailed_location | 143 | 100% | ||||
| health_condition_detail | 143 | 100% | 143 | |||
| location_region | 143 | 100% | 143 | |||
| sex | 143 | 100% | 143 | |||
| timepoint_label | 143 | 100% | 143 |
Archive description
Patients with cirrhosis and portal hypertension were prospectively enrolled prior to initiating lactulose. Patients had no antibiotic or alcohol use in the prior month. At baseline and at 4 weeks, all patients underwent the animal naming test (ANT) and fecal samples for metagenomic and 16S rRNA gene amplicon sequencing and targeted metabolite analysis.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbiota in patients”
- body site study.description · “test (ANT) and fecal samples for metagenomic”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.host_age · “64 (n=98/143)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN61455179 | age_at_collection_days | 27759.0 | R1 | 0.70 | sample.attr.host_age | 76 |
| SAMN61455179 | collection_date | 2023 | R1 | 0.90 | biosample.attribute:collection_date | 2023 |
| SAMN61455179 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: Michigan |
| SAMN61455179 | health_condition | liver_disease | R1 | 0.90 | biosample_attr | Cirrhosis |
| SAMN61455179 | health_condition_detail | Cirrhosis | R1 | 0.90 | sample.attr.host_disease | Cirrhosis |
| SAMN61455179 | location_region | Michigan | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Michigan |
| SAMN61455179 | sex | female | R1 | 0.90 | sample.attr.host_sex | female |
| SAMN61455179 | subject_id | LAC1S001 | R1 | 0.85 | sample.attr.host_subject_id | LAC1S001 |
| SAMN61455179 | timepoint_label | 0 | R1 | 0.85 | sample.attr.sample_day | 0 |
Sequencing
143 runs over 143 samples · mean 1.21 Gbp per run (median 0.77 Gbp, total 172.92 Gbp; 143 runs with a base count) · layout PAIRED 143 · platform ILLUMINA 143 · models Illumina NovaSeq 6000 (143) · 0% of runs with a Sandpiper profile · first public 2026-07-08
Authors (0)
No author record.
Downloads
PRJNA1491285.csv.gz (4.4 KB) · parquet (75.5 KB) — all 143 samples, every field with route and confidence · PRJNA1491285_determinations.csv.gz (7.2 KB) — 1,287 evidence rows