Gut microbiome in UC patients with sarcopenia, Beijing
Case-control study of 92 samples from hospitalized active ulcerative colitis patients and age-matched healthy controls at Peking Union Medical College Hospital, comparing gut microbiome composition and function by sarcopenia status. machine-written summary
92 samples · 92 runs · CN · Adult · 2026 · 13.61 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 644 sample values (collection date, country, health condition, health condition detail, latitude, location locality, longitude) |
| ✓ Abstract / description | 92 sample values (subject id) |
| ✓ Full text | 92 sample values (location site) · PMC13581694 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 92 | 100% | ||||
| country | 92 | 100% | 92 | |||
| health_condition | 92 | 100% | 92 | |||
| subject_id | 92 | 100% | 92 | |||
| collection_date | 92 | 100% | 92 | |||
| detailed_location | 92 | 100% | ||||
| health_condition_detail | 92 | 100% | 92 | |||
| latitude | 92 | 100% | 92 | |||
| location_locality | 92 | 100% | 92 | |||
| location_site | 92 | 100% | 92 | |||
| longitude | 92 | 100% | 92 |
- Sarcopenia in patients with active ulcerative colitis: associations with serum metabolites and gut microbiota. 2026 PMID 42755660 PMC13581694 own_data
Archive description
Sarcopenia is increasingly recognized as a clinically important complication of inflammatory bowel disease (IBD). However, most prior studies have focused exclusively on the prognostic implications of sarcopenia in IBD, leaving a critical gap in our understanding of its pathogenesis. The gut-muscle axis has emerged as a novel framework for understanding the complex bidirectional communication between the gastrointestinal system and skeletal muscle, and gut microbiota is considered as the core regulater of this axis. In this study, we have enrolled hospitalized patients with active ulcerative colitis (UC) in the department of Gastroenterology of Peking Union Medical College Hospital, and compared the composition and function of the gut microbiome between UC patients with and without sarcopenia.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbial characteristics of”
- body site study.description · “its pathogenesis. The gut -muscle axis has”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN61881627 | collection_date | 2022-11-02 | R1 | 0.90 | biosample.attribute:collection_date | 2022-11-02 |
| SAMN61881627 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Beijing |
| SAMN61881627 | health_condition | ulcerative_colitis | R1 | 0.70 | sample.name_rule:library_names | UC-S1 |
| SAMN61881627 | health_condition_detail | UC-S | R1 | 0.70 | sample.name_rule:library_names | UC-S1 |
| SAMN61881627 | latitude | 39.9000 | R1 | 0.90 | biosample.attribute:lat_lon | 39.9 N 116.3 E |
| SAMN61881627 | location_locality | Beijing | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Beijing |
| SAMN61881627 | location_site | Peking Union Medical College Hospital | R3 | 0.70 | paper.fulltext.methods | Department of Gastroenterology, Peking Union Medical College Hospital (PUMCH) |
| SAMN61881627 | longitude | 116.3000 | R1 | 0.90 | biosample.attribute:lat_lon | 39.9 N 116.3 E |
| SAMN61881627 | subject_id | SAMN61881627 | R4 | 0.60 | design.one_sample_per_subject:abstract | Fifty-seven patients with active UC and 35 HCs were enrolled. |
Sequencing
92 runs over 92 samples · mean 13.49 Gbp per run (median 13.61 Gbp, total 1,240.91 Gbp; 92 runs with a base count) · layout PAIRED 92 · platform ILLUMINA 92 · models HiSeq X Ten (92) · 0% of runs with a Sandpiper profile · first public 2026-08-26
Authors (10)
Wei W first · Yan P · Wang F · Wang Q · Li C · Bai X · Zhang Y · Bao Y · Li J · Yu K last
Downloads
PRJNA1499619.csv.gz (3.7 KB) · parquet (75.2 KB) — all 92 samples, every field with route and confidence · PRJNA1499619_determinations.csv.gz (7.0 KB) — 828 evidence rows