Microencapsulated L. rhamnosus GG dose-response trial
90 samples from healthy adults in Ireland in a randomized, double-blind, two-period crossover trial testing dose-response effects of microencapsulated Lacticaseibacillus rhamnosus GG yogurt drink on gut microbiome composition. machine-written summary
90 samples · 90 runs · IE · Adult · 2026 · 5.02 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 630 sample values (country, health condition, health condition detail, intervention, intervention detail, subject id, timepoint) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Probiotic (live microorganisms; single strain or mixture) design crossover · population healthy_control · Microencapsulated Lacticaseibacillus rhamnosus GG yogurt drink, dose response
“microencapsulated Lacticaseibacillus rhamnosus GG in a yogurt drink” — study.title (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
23 of 23 people sampled more than once (90 samples; median 4, up to 4 per person). Schedule stated by the source: “Repeated stool sampling per subject at study_day 0,28 (period 1: baseline, end of treatment) and 42,70 (period 2: baseline, end of treatment) in a two-period crossover trial” (time origin: study/period enrolment (period 1 start)); stated follow-up 2 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 90 | 100% | ||||
| country | 90 | 100% | 90 | |||
| health_condition | 90 | 100% | 90 | |||
| subject_id | 90 | 100% | 90 | |||
| health_condition_detail | 90 | 100% | 90 | |||
| intervention | 90 | 100% | 90 | |||
| intervention_detail | 90 | 100% | 90 | |||
| timepoint_label | 90 | 100% | 90 |
Archive description
Probiotic efficacy is hypothesized to depend on reliable intestinal exposure, yet clinical evidence linking delivery engineering to measurable microbiome responses in humans remains limited. We evaluated dose response effects of microencapsulated Lacticaseibacil-lus rhamnosus GG on gastrointestinal tolerance and gut microbiome composition in 26 healthy adults in a randomized, double-blind, two period crossover trial.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_unknown_no_evidence”
- body site study.title · “yogurt drink on gut microbiome modulation in”
- body site study.description · “depend on reliable intestinal exposure, yet clinical”
- life stage study.title · “modulation in healthy adults : a randomized,”
- life stage study.description · “in 26 healthy adults in a randomized,”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN62451179 | country | IE | R1 | 0.90 | sample.attr.geo_loc_name | Ireland |
| SAMN62451179 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:description | Stool sample from de-identified healthy adult participant PD01, collected at T0 in a randomized double-blind |
| SAMN62451179 | health_condition_detail | healthy | R1 | 0.70 | sample.name_rule:description | Stool sample from de-identified healthy adult participant PD01, collected at T0 in a randomized double-blind |
| SAMN62451179 | intervention | no_intervention | R1 | 0.80 | biosample.attribute:study_timepoint | study_timepoint: T0 |
| SAMN62451179 | intervention_detail | baseline before probiotic dosing | R1 | 0.80 | biosample.attribute:study_timepoint | study_timepoint: T0 |
| SAMN62451179 | subject_id | PD01 | R1 | 0.85 | sample.attr.host_subject_id | PD01 |
| SAMN62451179 | timepoint_label | period 1 | R1 | 0.85 | sample.attr.study_period | period 1 |
Sequencing
90 runs over 90 samples · mean 4.90 Gbp per run (median 5.02 Gbp, total 440.68 Gbp; 90 runs with a base count) · layout PAIRED 90 · platform ILLUMINA 90 · models NextSeq 2000 (90) · 0% of runs with a Sandpiper profile · first public 2026-08-18
Authors (0)
No author record.
Downloads
PRJNA1513476.csv.gz (3.3 KB) · parquet (73.3 KB) — all 90 samples, every field with route and confidence · PRJNA1513476_determinations.csv.gz (4.7 KB) — 630 evidence rows