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PRJNA1521393 SRP732022

Sterile fecal filtrate transfer for ulcerative colitis

First clinical cases of effective sterile fecal filtrate transfer for ulcerative colitis treatment: microbiome and virome shifts

11 adult gut microbiome/virome samples from an intervention study of sterile fecal filtrate transfer (FMT) for ulcerative colitis, compared with healthy donors. machine-written summary

11 samples · 11 runs · RU · Adult · 2026 · 0.29 Gbp / sample

Sources
✓Sequence archive 107–Abstract / description–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive107 sample values (collection date, country, health condition, health condition detail, intervention, latitude, location locality, location region)
– Abstract / descriptionno abstract or project description
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Interventions

intervention · arms resolved

before · no interventionbefore · no interventi3 samplesotherother6 samples
single arm: samples before and on the intervention

3 people have samples in more than one arm.

Faecal microbiota transplantation design single_arm_before_after · population ulcerative_colitis · Sterile fecal filtrate transfer (filtrate FMT) from healthy donors to UC patients

“sterile fecal filtrate transfer for ulcerative colitis treatment” — study.title (study level; per-sample arms are in the intervention column below)

Samples at a glance
1 sampling locations · 1 country
Age
adult11
Condition
ulcerative_colitis9
healthy_control1
Country
RU11
Body site
primary11
Collected 2022–2023
2022: 7 samples2023: 4 samples20222023
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)this project, 0.03–0.1 Gbp: 2 samplesall projects, 0.1–0.3 Gbp: 29,179 samples (5 %)this project, 0.1–0.3 Gbp: 4 samplesall projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 2 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 3 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)all projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 0.29 Gbp per sample0130Gbp
! Self-contradictory metadata

health condition: two sample namess disagree for 1 sample (e.g. healthy_control vs crohns_disease) — withheld.

The sources disagree on 1 sample. Where two incompatible values exist for one sample (or one person's samples disagree on sex), neither value is published: the field is left empty here, in the sample sheet and in the downloads. Both sides, with their sources, are in gut_metadata_contradictions.parquet of the data package (what counts as a contradiction).

Contradicted values (1)
samplefieldvalueother valuehandling
SAMN62799919health conditionhealthy_control (sample names)crohns_disease (sample names)withheld: neither value published
Sampling design and relatedness

longitudinalFMT donor → recipient — not resolved

3 of 5 people sampled more than once (9 samples; median 3, up to 3 per person) · follow-up median 3 mo (max 3 mo) · median interval between samples 45 d (time from collection months (month precision)). Schedule stated by the source: “Patients sampled before SFT, one month after SFT, and three months after SFT”; stated follow-up 3 mo.

Patient 1Patient 1: day 0Patient 1: day 31Patient 1: day 92Patient 2Patient 2: day 0Patient 2: day 31Patient 2: day 92Patient 3Patient 3: day 0Patient 3: day 31Patient 3: day 900 d23 d46 d2 mo3 mo

Each row is one person (3 shown); dots are samples at days since that person's first sample.

3 UC patients before/1 mo/3 mo after sterile faecal filtrate transfer plus 2 sequenced donors; donor-patient pairing not stated.

How longitudinal and relatedness information is derived

Community composition

No Sandpiper profile for this project's samples yet.

Field coverage
fieldsamplescoverageR1R2R3R4
age_category11 100%
country11 100%11
health_condition10 91%10
subject_id11 100%11
collection_date11 100%11
detailed_location11 100%
health_condition_detail11 100%11
latitude11 100%11
location_locality11 100%11
location_region11 100%11
longitude11 100%11
intervention9 82%9
Details
Archive description

The goal is to assess the impact of successful sterile fecal filtrate transfer on patients' gut microbiome and virome in comparison to healthy donors.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
  • body site study.title · “of effective sterile fecal filtrate transfer for”
  • body site study.description · “of successful sterile fecal filtrate transfer on”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN62799909collection_date2022-05R10.90biosample.attribute:collection_date2022-05
SAMN62799909countryRUR10.90sample.attr.geo_loc_nameRussia: Novosibirsk
SAMN62799909health_conditionulcerative_colitisR10.70sample.name_rule:aliasPatient 1 stool before SFT
SAMN62799909health_condition_detailbeforeR10.70sample.name_rule:aliasPatient 1 stool before SFT
SAMN62799909interventionno_interventionR10.70sample.name_rule:aliasPatient 1 stool before SFT
SAMN62799909latitude55.0300R10.90biosample.attribute:lat_lon55.03 N 82.57 E
SAMN62799909location_localityNovosibirskR10.85biosample.attribute:geo_loc_nameRussia: Novosibirsk
SAMN62799909location_regionNovosibirskR10.60biosample.attribute:lat_lon55.03 N 82.57 E
SAMN62799909longitude82.5700R10.90biosample.attribute:lat_lon55.03 N 82.57 E
SAMN62799909subject_idPatient 1R10.70sample.name_rule:aliasPatient 1 stool before SFT
Sequencing

11 runs over 11 samples · mean 0.56 Gbp per run (median 0.29 Gbp, total 6.13 Gbp; 11 runs with a base count) · layout PAIRED 11 · platform ILLUMINA 11 · models Illumina MiSeq (11) · 0% of runs with a Sandpiper profile · first public 2026-09-02

Authors (0)

No author record.

Downloads

PRJNA1521393.csv.gz (1.3 KB) · parquet (71.1 KB) — all 11 samples, every field with route and confidence · PRJNA1521393_determinations.csv.gz (1.5 KB) — 107 evidence rows

Samples (11 · every field this project has values for · hover a cell for its source)
Loading the sample table…