Hospital outbreak cluster of astrovirus MLB and rotavirus C
6 stool/serum/tissue samples from a hospital diarrhoea outbreak among healthcare workers (5 adults, 1 elderly), investigating human astrovirus MLB and rotavirus C infection, including one fatal case. machine-written summary
6 samples · 6 runs · HK · Adult · 2026 · 0.28 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 21 sample values (age, collection date, country, subject id) |
| ✓ Abstract / description | 12 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
workplace — not resolved
Hospital diarrhoea outbreak in healthcare workers (staff a, b) plus archived patients; not committed per sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 6 | 100% | ||||
| country | 6 | 100% | 6 | |||
| health_condition | 6 | 100% | 6 | |||
| subject_id | 3 | 50% | 3 | |||
| age_at_collection_days | 6 | 100% | 6 | |||
| collection_date | 6 | 100% | 6 | |||
| health_condition_detail | 6 | 100% | 6 |
Archive description
A hospital outbreak cluster of diarrhoea with one death in three previously healthy healthcare workers, with inconclusive negative multiplex polymerase chain reaction (PCR) for common gastroenteritis agents, was investigated. Further next-generation sequencing and viral culture on the stool revealed rotavirus C (RVC) and human astrovirus MLB (HastV-MLB) in the deceased doctor. Subsequent PCR confirmed the presence of HastV-MLB RNA in stool from another healthcare worker involved. While the viral load of RVC was high in serum, stool, and other tissue specimens in the deceased who succumbed fromto shock and disseminated intravascular coagulation, the viral load of HastV-MLB was low. Fatal outcomes associated with RVC are rare, and causality in this case remains uncertain due to multiple confounders. No fatal Rotavirus C case has been reported previously. It is important to consider these rare agents in diarrheal outbreaks or unusually severe gastroenteritis, especially when preliminary investigations are unremarkable.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.60. Assay shotgun_dna.
- host study.description · “three previously healthy healthcare workers”
- body site study.description · “revealed rotavirus C (RVC) and human astrovirus MLB”
- life stage study.description · “healthcare workers”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN62804475 | age_at_collection_days | 9131.0 | R1 | 0.85 | sample.attr.host_age | 25 |
| SAMN62804475 | collection_date | 2025 | R1 | 0.90 | biosample.attribute:collection_date | 2025 |
| SAMN62804475 | country | HK | R1 | 0.90 | sample.attr.geo_loc_name | Hong Kong |
| SAMN62804475 | health_condition | gi_infection_or_diarrhoea | R4 | 0.50 | study.description | rotavirus C (RVC) and human astrovirus MLB (HastV-MLB) |
| SAMN62804475 | health_condition_detail | Hospital outbreak of diarrhoea with RVC and HastV-MLB coinfection | R4 | 0.50 | study.description | rotavirus C (RVC) and human astrovirus MLB (HastV-MLB) |
| SAMN62804478 | subject_id | a | R1 | 0.70 | sample.name_rule:alias | staff_a_SISPA_RS_rotC |
Sequencing
6 runs over 6 samples · mean 0.68 Gbp per run (median 0.28 Gbp, total 4.10 Gbp; 6 runs with a base count) · layout SINGLE 6 · platform OXFORD_NANOPORE 6 · models MinION (6) · 0% of runs with a Sandpiper profile · first public 2026-09-02 – 2026-09-03
Authors (0)
No author record.
Downloads
PRJNA1521563.csv.gz (1.1 KB) · parquet (70.0 KB) — all 6 samples, every field with route and confidence · PRJNA1521563_determinations.csv.gz (972 B) — 33 evidence rows